Salt/ water reabsorption in kidney

Question 1

What channel is affected by PHAII?

Answer 1

NCC- sodium chloride cotransporter

Question 2

What cell are NCC channels found on?

Answer 2

Renal epithelial cell

Question 3

Which part of the nephron are NCC channels found?

Answer 3

DCT

Question 4

Which membrane are NCC channels found?

Answer 4

Luminal membrane

Question 5

What drives sodium influx through the NCC?

Answer 5

Sodium efflux by the Na+ K+ ATPase

Question 6

What does the Na+ K+ ATPase do?

Answer 6

3Na+ out (into blood capillary)

2K+ into renal epithelial cell

Question 7

Where is the Na+ K+ ATPase found?

Answer 7

Basolateral membrane of the renal epithelial cell in the DCT

Question 8

How is Cl- transported from the renal epithelial cell to the blood capillary?

Answer 8

Voltage-gated Chloride Channel on basolateral membrane (Chloride channel Kb)

Question 9

Where is water reabsorbed?

Answer 9

PCT/ descending limb of LoH/ Collecting duct

Question 10

What % of Na is reabsorbed in the DCT?

Answer 10

5%

Question 11

What type of channels does water flow through in the kidney?

Answer 11

Aquaporins (AQP)

Question 12

Where is AQP1 found?

Answer 12

PCT- Luminal and basolateral membranes

Question 13

Where is AQP7 found?

Answer 13

Late PCT- Luminal membrane