Salivary Glands Flashcards
Salivary duct anatomy
acinus (surrounded by myoepithelial cells)
⇒ intercalated duct
⇒ striated duct
⇒ excretory duct
Saliva electrolytes
High K
Low Na
Parotid saliva
Watery (high serous cells)
High enzymes
Low mucin
SMG / SLG saliva
SMG - mixed serous and mucin
SLG - mostly mucin
Antibacterial activity of saliva
IgA
lysozymes
leukotaxins
opsonins
Granulomatous (infectious) sialadenitis causes
Frequent in HIV Actinomycosis Cat scratch Sarcoid TB Wegener's
Heerfordt’s disease
uveoparotid fever (sarcoid) =
- uveitis
- mild fever
- non-suppurative parotitis
- CN 7 paralysis
Sjögren disease Rx
Pilocarpine (Salagen)
— cholinergic agonist for post-XRT and SD
Cevimeline (Evoxac)
—cholinergic agonist for SD and second-line for post-XRT
Post-XRT Xerostomia Rx
Amifostine - chemoprotectant
Pilocarpine (Salagen)
Cevimeline (Evoxac)
Pleomorphic adenoma (benign mixed tumor) histo
epithelial
myoepithelial
stromal elements
Warthin histo
papillary cystadenoma lymphomatosum
Oncocytoma histo
sheets, nests, or cords of oncocytes (granular-appearing cells)
Mucoepidermoid ca histo
Low
- Higher ratio of mucous to epidermoid cells
- Presence of cystic spaces
High
- Higher ratio of epidermoid to mucous cells
- May resemble SCCA
MC parotid ca
Mucoep
MC SMG and minor SG ca
Adenoid cystic
