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Salivary Flashcards

1
Q

Most common causes of sialadenosis (non-inflammatory enlarge of glands)

A

DM, bulimia, alcoholism, malnutrition

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2
Q

Leafless tree

A

sialography finding in sialadenosis

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3
Q

In Sialadenosis acinar cells are enlarged and the cytoplasm is full of ____

A

zymogen granules

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4
Q

adenomatoid hyperplasia of the minor salivary glands

A

pseudotumor, localized swelling of minor salivary glands, look like normal acini that are just greater in number than usual

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5
Q

Most common site of all salivary gland tumors

A

Parotid 61-80%

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6
Q

What % of salivary gland tumors are in the submandibular gland

A

8-11%

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7
Q

What percent of parotid gland tumors are warthin tumors

A

5-22%

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8
Q

__% of salivary gland tumors occur in the sublingual gland. Of those tumor what percent are malignant

A

1%; 70-95%

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9
Q

Second most common site for salivary gland tumors

A

Minor glands: 9-28%.

42-54% of these are on the palate

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10
Q

What % of salivary tumors occurring on the lips are on the upper lip. What % of these tumors are malignant?

A

74-87%

9-25% of upper lip salivary gland tumors are malignant

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11
Q

What % of lower lip salivary gland tumors are malignant

A

tumors are much more rare in this location but much more frequently malignant 43-86%

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12
Q

A salivary gland tumor that occurs _______, has a 95% chance of being malignant

A

retromolar pad

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13
Q

What % of minor salivary gland tumors are malignant

A

38-49%

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14
Q

Most common salivary neoplasm

A

Pleomorphic adenoma

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15
Q

What translocation is characteristic in PA (occurs in 70% of tumors)

A

PLAG1- pleomorphic adenoma gene chromo region 8q12

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16
Q

Most PAs occur in the ___lobe of the parotid

A

superficial lobe

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17
Q

What causes a dumbbell shaped tumor mass that may be seen on the pharyngeal wall or soft palate

A

PA growing within the deep lobe of the parotid (10%)

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18
Q

what cells produce the characteristic stroma of a PA

A

myoepithelial cells

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19
Q

PAs with a higher % of ___ recur more

A

higher myxoid component

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20
Q

What % of PAs transform to carcinoma ex pleomorphic adenoma

A

3-4%

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21
Q

Another name for oncocytoma

A

oxyphilic adenoma

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22
Q

__% of oncocytomas are found in the parotid gland

A

85-95%

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23
Q

What stains are positive in oncocytes

A

PTAH- phosphotungstic acid and hemotoxylin
PAS+
PASD-

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24
Q

Oncocytomas occurring in what site are considered low grade malignancies

A

sinonasal glands (agressive behavior)

25
Diffuse hyperplastic oncocytosis
when the entire gland is replaced by oncocytes
26
Smoking increased risk for warthin tumor by ___X
8x
27
What salivary gland tumor occurs in the tail of the parotid
warthin tumor
28
what % of warthin tumors are bilateral
5-17%
29
% of canalicular adenomas that occur in the upper lip
75%
30
What salivary gland neoplasms have both epithelial and myoepithelial cells
PA, basal cell adenoma, adenoid cystic, polymorphous adeno
31
Most frequent location of basal cell adenomas
parotid gland 75%
32
One important subtype of basal cell adenoma and its signficance
membranous basal cell adenoma | It occurs in conjunction with skin appendage tumors: cylindromas and trichoepitheliomas
33
What is the recurrence rate of dermal analogue tumors
aka membranous basal cell adenomas | 25-37% recurrence rate
34
characteristic histologic pattern of membranous basal cell adenoma
jigsaw pieces surrounded by duplicated basement membrane
35
What salivary gland tumors can show a cribriform pattern
adenoid cystic, polymorphous adenocarcinoma, basal cell adenoma
36
3 types of ductal papillomas
1. Sialadenoma papiliferum 2. Intraductal papilloma 3. Inverted ductal papilloma
37
___ is an analogue to cutaneous syringocystadenoma papilliferum
sialadenoma papilliferum
38
typical inflammatory infiltrate in sialadenoma papilliferum
plasma cells, lymphocytes, neutrophils
39
What ductal papilloma is HPV positive
inverted ductal papilloma 6 and 11
40
characteristic translocation of mucoep
t11;19 | CRTC1-MAML2 fusion oncogene
41
survival rate in high grade mucoep
30-54%
42
Intraosseous mucoep most likely develops from
odontogenic epithelial
43
Most common site for acinic cell carcinom
parotid 80-95% of cases
44
Growth patterns of acinic cell carcinoma
Solid, papillary-cystic, microcystic, follicular
45
Characteristic genetic findings in mammary analogue secretory carcinoma
t12;15 (p13q25) | ETV6-NTK3 fusion gene
46
Most common site for mammary analogue secretory carcinoma
parotid- 58%
47
Salivary gland tumors in which M>F
Warthin tumor 10:1, Mammary analogue secretory carcinoam
48
What stains can help diagnose mammary analogue secretory carcinoma
S100+, mammaglobin+
49
What salivary gland malignancies are low grade
oncocytomas of the sinonasal glands, mammory analogue secretory carcinoma, low-grade mucoep, acinic cell carcinoma, polymorphous adenocarcinoma
50
Most frequently the carcinoma component of carcinoma ex pleomorphic adenoma is ___
poorly differentiated carcinoma such as salivary duct carcinoma
51
Another name for adenoid cystic carcinoma that is not used anymore
cylindroma
52
Most frequent site for adenoid cystic carcinoma
minor glands, specifically the palate
53
Most common malignant salivary gland tumor of the submandibular gland
adenoid cystic carcinoma
54
Unique clinical feature of adenoid cystic carcinoma
It frequently causes escalating pain, even in early stages
55
% of patients with metastatic disease in adenoid cystic carcinoma
35%-- lungs, bone, brain
56
5 year prognosis compared to 20 year for adenoid cystic
5yr 77-82% | 20yr 35-52%
57
Lobular carcinoma and terminal duct carcinoma are names for which salivary gland tumor
polymorphous adenocarcinoma
58
Tumors most common in minor salivary glands
polymorphous adenocarcinoma, adenoid cystic carcinoma, mucoep, all ductal papillomas, canalicular adenoma

Salivary (1 decks)

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