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Salivary > Salivary > Flashcards

Salivary Flashcards

1
Q

Most common causes of sialadenosis (non-inflammatory enlarge of glands)

A

DM, bulimia, alcoholism, malnutrition

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2
Q

Leafless tree

A

sialography finding in sialadenosis

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3
Q

In Sialadenosis acinar cells are enlarged and the cytoplasm is full of ____

A

zymogen granules

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4
Q

adenomatoid hyperplasia of the minor salivary glands

A

pseudotumor, localized swelling of minor salivary glands, look like normal acini that are just greater in number than usual

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5
Q

Most common site of all salivary gland tumors

A

Parotid 61-80%

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6
Q

What % of salivary gland tumors are in the submandibular gland

A

8-11%

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7
Q

What percent of parotid gland tumors are warthin tumors

A

5-22%

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8
Q

__% of salivary gland tumors occur in the sublingual gland. Of those tumor what percent are malignant

A

1%; 70-95%

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9
Q

Second most common site for salivary gland tumors

A

Minor glands: 9-28%.

42-54% of these are on the palate

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10
Q

What % of salivary tumors occurring on the lips are on the upper lip. What % of these tumors are malignant?

A

74-87%

9-25% of upper lip salivary gland tumors are malignant

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11
Q

What % of lower lip salivary gland tumors are malignant

A

tumors are much more rare in this location but much more frequently malignant 43-86%

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12
Q

A salivary gland tumor that occurs _______, has a 95% chance of being malignant

A

retromolar pad

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13
Q

What % of minor salivary gland tumors are malignant

A

38-49%

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14
Q

Most common salivary neoplasm

A

Pleomorphic adenoma

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15
Q

What translocation is characteristic in PA (occurs in 70% of tumors)

A

PLAG1- pleomorphic adenoma gene chromo region 8q12

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16
Q

Most PAs occur in the ___lobe of the parotid

A

superficial lobe

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17
Q

What causes a dumbbell shaped tumor mass that may be seen on the pharyngeal wall or soft palate

A

PA growing within the deep lobe of the parotid (10%)

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18
Q

what cells produce the characteristic stroma of a PA

A

myoepithelial cells

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19
Q

PAs with a higher % of ___ recur more

A

higher myxoid component

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20
Q

What % of PAs transform to carcinoma ex pleomorphic adenoma

A

3-4%

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21
Q

Another name for oncocytoma

A

oxyphilic adenoma

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22
Q

__% of oncocytomas are found in the parotid gland

A

85-95%

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23
Q

What stains are positive in oncocytes

A

PTAH- phosphotungstic acid and hemotoxylin
PAS+
PASD-

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24
Q

Oncocytomas occurring in what site are considered low grade malignancies

A

sinonasal glands (agressive behavior)

25
Q

Diffuse hyperplastic oncocytosis

A

when the entire gland is replaced by oncocytes

26
Q

Smoking increased risk for warthin tumor by ___X

A

8x

27
Q

What salivary gland tumor occurs in the tail of the parotid

A

warthin tumor

28
Q

what % of warthin tumors are bilateral

A

5-17%

29
Q

% of canalicular adenomas that occur in the upper lip

A

75%

30
Q

What salivary gland neoplasms have both epithelial and myoepithelial cells

A

PA, basal cell adenoma, adenoid cystic, polymorphous adeno

31
Q

Most frequent location of basal cell adenomas

A

parotid gland 75%

32
Q

One important subtype of basal cell adenoma and its signficance

A

membranous basal cell adenoma

It occurs in conjunction with skin appendage tumors: cylindromas and trichoepitheliomas

33
Q

What is the recurrence rate of dermal analogue tumors

A

aka membranous basal cell adenomas

25-37% recurrence rate

34
Q

characteristic histologic pattern of membranous basal cell adenoma

A

jigsaw pieces surrounded by duplicated basement membrane

35
Q

What salivary gland tumors can show a cribriform pattern

A

adenoid cystic, polymorphous adenocarcinoma, basal cell adenoma

36
Q

3 types of ductal papillomas

A
  1. Sialadenoma papiliferum
  2. Intraductal papilloma
  3. Inverted ductal papilloma
37
Q

___ is an analogue to cutaneous syringocystadenoma papilliferum

A

sialadenoma papilliferum

38
Q

typical inflammatory infiltrate in sialadenoma papilliferum

A

plasma cells, lymphocytes, neutrophils

39
Q

What ductal papilloma is HPV positive

A

inverted ductal papilloma 6 and 11

40
Q

characteristic translocation of mucoep

A

t11;19

CRTC1-MAML2 fusion oncogene

41
Q

survival rate in high grade mucoep

A

30-54%

42
Q

Intraosseous mucoep most likely develops from

A

odontogenic epithelial

43
Q

Most common site for acinic cell carcinom

A

parotid 80-95% of cases

44
Q

Growth patterns of acinic cell carcinoma

A

Solid, papillary-cystic, microcystic, follicular

45
Q

Characteristic genetic findings in mammary analogue secretory carcinoma

A

t12;15 (p13q25)

ETV6-NTK3 fusion gene

46
Q

Most common site for mammary analogue secretory carcinoma

A

parotid- 58%

47
Q

Salivary gland tumors in which M>F

A

Warthin tumor 10:1, Mammary analogue secretory carcinoam

48
Q

What stains can help diagnose mammary analogue secretory carcinoma

A

S100+, mammaglobin+

49
Q

What salivary gland malignancies are low grade

A

oncocytomas of the sinonasal glands, mammory analogue secretory carcinoma, low-grade mucoep, acinic cell carcinoma, polymorphous adenocarcinoma

50
Q

Most frequently the carcinoma component of carcinoma ex pleomorphic adenoma is ___

A

poorly differentiated carcinoma such as salivary duct carcinoma

51
Q

Another name for adenoid cystic carcinoma that is not used anymore

A

cylindroma

52
Q

Most frequent site for adenoid cystic carcinoma

A

minor glands, specifically the palate

53
Q

Most common malignant salivary gland tumor of the submandibular gland

A

adenoid cystic carcinoma

54
Q

Unique clinical feature of adenoid cystic carcinoma

A

It frequently causes escalating pain, even in early stages

55
Q

% of patients with metastatic disease in adenoid cystic carcinoma

A

35%– lungs, bone, brain

56
Q

5 year prognosis compared to 20 year for adenoid cystic

A

5yr 77-82%

20yr 35-52%

57
Q

Lobular carcinoma and terminal duct carcinoma are names for which salivary gland tumor

A

polymorphous adenocarcinoma

58
Q

Tumors most common in minor salivary glands

A

polymorphous adenocarcinoma, adenoid cystic carcinoma, mucoep, all ductal papillomas, canalicular adenoma

Salivary (1 decks)

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