Salamander question Flashcards
What is step one of limb regeneration?
Blood and immune cells flood the amputated area, and a blood clot quickly forms
What is step two of limb regeneration?
Wounding triggers an activation of stem/progenitor cell proliferation
What is step three of limb regeneration?
Epidermal cells along the edge of the cut migrate over the wound to form a wound epidermis
What is step four of limb regeneration?
Through cell proliferation and continued migration, the wound epidermis thickens into an apical epidermal cap (AEC)
What is step five of limb regeneration?
Signals from the AEC to the amassing population of progenitor cells underneath it foster development of the regeneration blastema
What is step six of limb regeneration?
Continued proliferation and progressive differentiation of the blastema fuel the outgrowth of the limb regenerate
Why can humans not regenerate limb?
Humans can regenerate certain structures such as the liver by COMPENSATORY REGENERATION
What is required for regeneration?
- Morphological memory map prior to injury
- Recognition of change following injury
- Wound healing
- Regenerative response
- Stopping regeneration once its at the correct size and shape
