Sabiston Appendix Flashcards

1
Q

appendix may serve as a reservoir of “good” intestinal bacteria and may aid in recolonization and maintenance of the normal colonic flora

A

patients who have had previous appendectomy have been demonstrated to have a more difficult clinical course and overall poorer outcomes in recurrent cases of Clostridium difficile infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Appendix Size and how to identify

A
  • appendix is of variable size (5–35 cm in length) but averages 8 to 9 cm in length in adults.
  • Its base can be reliably identified by defining the area of convergence of the taeniae at the tip of the cecum
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

MC location for Appendix Tip

A
  • most common being retrocecal (but intraperitoneal) in approximately 60% of individuals
  • pelvic in 30%,
  • retroperitoneal in 7% to 10%.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Amyand Appendix

A

Appendix found within an inguinal hernia sac

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

The most common sequela in Appendicitis

A
  • formation of an abscess in the periappendiceal region or pelvis
  • On occasion, however, free perforation occurs that results in diffuse peritonitis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Bacteria commonly isolated in perforated appendicitis

A

Gram-Negative Bacteria
Escherichia coli MC 64%

Gram-Positive Bacteria
Enterococcus species 3.9%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Causes of Appendicitis

A

most commonly include
- fecal stasis and fecaliths
- Lymphoid hyperplasia
- neoplasms
- fruit and vegetable material
- ingested barium
- parasites such as ascaris or pinworm infestation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Appendix Pain

A
  • Distention of the appendix is responsible for the initial vague abdominal pain (visceral) often experienced by the affected patient.
  • The pain typically does not localize to the right lower quadrant until the tip becomes inflamed and irritates the adjacent parietal peritoneum (somatic) or perforation occurs, resulting in localized peritonitis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Rovsing sign, obturator sign, psoas sign

A
  • Rovsing sign (the presence of right lower quadrant pain on palpation of the left lower quadrant)
  • the obturator sign (right lower quadrant pain on internal rotation of the hip)
  • the psoas sign (pain with extension of the ipsilateral hip)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Alvarado score sensitivity

A

sensitivity of an Alvarado score of <4 was most useful in excluding a diagnosis of appendicitis (96% sensitive)

but that a higher score lacked specificity in diagnosing appendicitis as the cause of the patient’s abdominal pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

The Alvarado score

A

Interpretation:

<4 Appendicitis unlikely

5–6 Compatible with appendicitis

7–8 Probable appendicitis

9–10 Very probable appendicitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

CT findings in appendicitis

A

thickened, inflamed appendix with surrounding “stranding” indicative of inflammation

The appendix is typically more than 7 mm in diameter with a thickened, inflamed wall and mural enhancement or “target sign”

Periappendiceal fluid or air is also highly suggestive of appendicitis and suggests perforation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

When to used US for Appendix

A

evaluation of the pediatric or pregnant patient

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

MRI ?

A
  • reserved for use in the pregnant patient
  • performed without contrast agents.

Criteria for MRI diagnosis include appendiceal enlargement (>7 mm), thickening (>2 mm), and the presence of inflammation.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

open appendectomy

A
  • supine position
  • incision :
  • oblique muscle-splitting incision (McArthur-McBurney)
  • transverse incision (Rockey-Davis)
  • conservative midline incision.
  • The cecum is grasped by the taeniae and delivered into the wound
  • visualization of the base of the appendix
  • delivery of the appendiceal tip.
  • The mesoappendix is divided
  • appendix is crushed just above the base
  • ligated with an absorbable ligature, and divided.
  • The stump is then either cauterized or, if desired, inverted by a purse-string or “Z” suture technique. Finally, the abdomen is irrigated and the wound closed in layers.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

When to use stapler in appendicitis

A

the appendix and mesoappendix may be divided with an endoscopic stapling device. We prefer this technique in cases in which the entire appendix is friable because it allows the staple line to be placed slightly more proximally, on the edge of the healthy cecum, thereby theoretically reducing the risk of leakage from breakdown of a tenuous appendiceal stump.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

does perforated appendicitis requires C/S ?

A

Cultures are not mandatory unless the patient has had exposure to a health care environment or has had recent exposure to antibiotic therapy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Do you do Suction and irrigation , and Drain ?

A

Although large volume irrigation has been traditionally advocated, recent data suggest that simple suction aspiration of gross purulence may be just as effective in cases of appendiceal rupture.

Drains are not routinely placed unless a discrete abscess cavity is present.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

How to close Skin in open technique

A

If an open technique was used, the skin and subcutaneous tissues are left open for 3 or 4 days to prevent development of wound infection, at which time delayed primary closure may be performed at the bedside with sutures, surgical skin clips, or Steri-Strips, depending on the surgeon’s preference.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Post op in perf app , When to stop abx and start feed

A

broad-spectrum antibiotics for 4 to 7 days

If culture specimens were obtained, antibiotic therapy should be modified in accordance with the results.

Nasogastric suction is not employed routinely but may be necessary if postoperative ileus develops.

Oral alimentation is begun after return of bowel sounds and passage of flatus and is advanced as tolerated.

Once the patient is tolerating a diet, is afebrile, and has a normal white blood cell count, the patient may be discharged home.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

If the patient develops fever, leukocytosis, pain, and delayed return of bowel function post op

A

the possibility of a postoperative abscess must be entertained.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

In complicated appendicitis, laparoscopic appendectomy had a higher what ?

A

was associated with fewer wound complications but a slightly higher incidence of intraabdominal abscess.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

delayed appendicitis with phlegmon ? how to Tx

A

If a periappendiceal phlegmon is present or if the amount of fluid present is not sufficient to drain, the patient may be treated with antibiotics alone, typically for 4 to 7 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Interval Appendectomy

A

the actual risk of recurrent appendicitis appears to be small, 8% at 8 years in one study of 6439 pediatric patients.

In addition, interval appendectomy can be challenging and consequently yield a higher risk of postoperative complications when performed

interval appendectomy should be reserved only for patients who present with symptoms of recurrent appendicitis.

the presence of an appendicolith on CT has also been shown to be predictive of a higher risk of recurrent appendicitis and has been used as a justification to proceed with interval appendectomy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
What to Do for them ? workup
colonoscopy is recommended in all adult patients as routine follow-up after nonoperative management of complicated appendicitis > appendiceal neoplasms > perforated tumors of the cecum
26
The Normal-Appearing Appendix at Operation
- The terminal 60 cm of ileum should be examined for a Meckel diverticulum - the serosa of the small bowel for any stigmata of Crohn disease, such as inflammation, stricture formation, or the characteristic “creeping fat” appearance of the mesentery. - Inspection of the ileal mesentery may reveal enlarged lymph nodes suggestive of mesenteric adenitis. - The uterine adnexa should be examined for any evidence of tubo-ovarian or salpingeal disease, such as ovarian torsion, tubo-ovarian abscess, endometriosis, or ruptured ovarian cysts. - The sigmoid colon should be examined for evidence of acute diverticulitis, especially in cases in which a redundant sigmoid colon is found in the right lower quadrant. - If these are all normal, attention should be turned to the upper abdomen for examination of the gallbladder and duodenum. - Inability to perform an adequate evaluation of the intraabdominal organs or demonstration of disease of other organs requiring intervention may require conversion to a midline laparotomy if necessary.
27
Why remove Appendix when it looks normal
-to rule out appendicitis -Appendectomy is also advisable in cases of Crohn disease when suggested by findings at operation, unless the base of the appendix and cecum are involved > Risk of Fistula - abnormalities of the appendix not apparent on gross inspection at the time of operation are sometimes identified on pathologic examination
28
Delayed app
29
Non operative for uncomplicated App
- associated with a lower risk of complications (12% in the nonoperative group vs. 18% in the appendectomy group; P = 0.001). - displayed no greater tendency to progress to complicated appendicitis. - Appendectomy, however, outperformed the nonoperative group in overall treatment failure rate (38% nonoperative vs. 9% in the appendectomy group; P < 0.001).
30
non op management of non comp appendicitis
The investigators reported a recurrence rate of 27% at the 1-year mark
31
round ligament pain
Lower quadrant pain in the second trimester produced by traction on the suspensory ligaments of the uterus
32
Which trimester MC present with Appendicitis
50% of cases of appendicitis occur in the second trimester
33
risk of preterm labor and fetal loss
The risk of preterm labor has been shown to be 11% and fetal loss 6% with complicated appendicitis
34
negative appendectomy preterm labor and fetal loss
negative appendectomy was also associated with preterm labor and fetal loss (10% and 4%, respectively)
35
US positioning in pregnant
Scanning patients in a left posterior oblique or left lateral decubitus position rather than in the traditional supine position has been advocated to increase the chances of visualizing the appendix.
36
Routine use of MRI in pregnant patients has been demonstrated to reduce the negative appendectomy by
by 47%
37
CT Scan Pregnant ?
if CT is used during pregnancy for equivocal cases, care should be taken to perform as limited a study using the lowest possible radiation exposure technique and with avoidance of intravenous administration of contrast material.
38
Pregnant with appendicitis , which technique to insert trocar ?
At operation, consideration should be given to the height of the gravid uterus in choosing sites for trocar placement to avoid inadvertent puncture of the uterus. We routinely use an open access approach (Hasson technique) with fingertip entry into the abdomen
39
Elderly Patient with appendicitis have high perf rate ? true or false ?
The higher perforation rate in the elderly population, as high as 40% to 70%,
40
Old patient who cannot tolerate GA ?
we have successfully performed open appendectomy under spinal anesthesia in patients who are “pulmonary cripples” and in whom the risk of general anesthesia is prohibitive and likely to result in ventilator dependence
41
Immunocompromised Patient, rule out what ?
neutropenic enterocolitis (typhlitis)
42
Pregnant with App
43
What percentage of appendiceal neoplasm present as appendicitis
It is estimated that as many as 50% of appendiceal neoplasms present as appendicitis
44
what is the most common primary tumor identified in the appendix
Appendiceal neuroendocrine neoplasms (ANENs)—once referred to in aggregate as carcinoids—are the most common primary tumor identified in the appendix, comprising approximately 65% of all appendiceal neoplasms
45
Where its location, and which age group
from neuroendocrine cells from within the appendix located within the more distal aspect of the appendix. They are most commonly diagnosed in the second or third decade of life.
46
what is the initial predictor of malignant behavior and metastatic potential
Size appears to be the best initial predictor of malignant behavior and metastatic potential
47
< 1 cm and > 2 cm Tx ?
1 cm or smaller > behave in a benign manner > appendectomy with excision of the mesoappendix larger than 2 cm > right hemicolectomy and regional lymphadenectomy for adequate treatment
48
You should look for what to predict worse prognosis
Ki-67 index (>3%), as a high proliferative index portends a worse prognosis and also warrants right hemicolectomy for proper staging and treatment. The same is true for Grade 2 or greater tumors or those showing lymphovascular or perineural invasion
49
Tumor Marker ??
After definitive treatment measurement of serum chromogranin A serves as a useful tumor marker.
50
Adenocarcinoma of the appendix
rare Treatment is identical to that of cecal adenocarcinoma and consists of right hemicolectomy with regional lymphadenectomy. staging of adenocarcinoma of the colon, retrieval of more than 12 lymph nodes FolFox
51
Mucinous tumors of the appendix
- Low-grade appendiceal mucinous neoplasms (AMNs) : - Advanced-stage AMNs may present with advanced-stage disease and associated pseudomyxoma peritonei (PMP)
52
Early classification schemes considered AMN a benign disease
appendiceal mucocele cystadenoma cystadenocarcinoma
53
It is also important to note that all AMNs may result in
PMP regardless of their malignant potential
54
“low-grade AMN” has replaced the term
“benign mucocele.”
55
The Ronnet scheme divides more clinically advanced AMNs into three major variants:
1- disseminated peritoneal adenomucinosis (DPAM), 2- peritoneal mucinous carcinomatosis (PMCA) 3- PMCA of indeterminant or discordant features
56
DPAM Vs PMCA
- DPAM have an indolent course without distant extraperitoneal spread - PMCA are far more likely to develop metastasis to lymph nodes and extraperitoneal organs, thus suffering a worse prognosis
57
Low-grade AMNs less than 2 cm
appendectomy alone (with excision of the mesoappendix), with right hemicolectomy reserved for cases in which a positive margin is present, involvement of the appendiceal base, those exhibiting extra appendiceal extension, or those with invasive histology (adenocarcinoma) on final pathologic examination.
58
If PMP or peritoneal metastases occur,
treatment by extensive cytoreductive surgery combined with heated intraperitoneal chemotherapy (CRS-HIPEC) is typically employed
59
Chemo and Hipec
Systemic chemotherapy may also be used in combination with HIPEC at the discretion of the treating oncologist, with 5-fluorouracil–based therapies as the mainstay of adjuvant treatment
60
HIPEC
- The goal of the operation > remove all tumor burden that can be possibly removed at operation - remove all macroscopic tumor via peritoneal stripping and excision of involved organs - involve omental excision, hysterectomy, colectomy, splenectomy, cholecystectomy, liver capsulectomy, and peritonectomy of the parietal, diaphragmatic, and pelvic surfaces. - Heated chemotherapy (40.0°C) is then instilled into the peritoneal space and allowed to dwell. - Mitomycin C is the most commonly used agent, although cisplatin and oxaliplatin are also sometimes administered. The goal is to achieve maximum eradication of residual tumor burden while limiting systemic toxicity by administering the chemotherapy locally
61
Approach to App Neoplasm