SABA, LABA, LABA+ICS, LAMAs

Question 1

Salbutamol/ Albuterol

Answer 1

Ventolin
SABA
Available as: MDI, DPI (diskus), nebule
Dosage: MDI -100mcg (qid) , DPI - 200mcg, SVN - 2.5mg/0.5ml
Onset: 15 minutes
Peak: 30-60 minutes
duration: 4-6 hours

Question 2

Terbutaline

Answer 2

Bricanyl
SABA
Available as: turbuhaler
Dosage: MDI - 0.5mg qid
Onset: 15 minutes
Peak: 60-90 minutes
duration: 4-6 hours

Question 3

Ipratropium Bromide

Answer 3

Atrovent
SAMA** not saba
Available as: MDI, nebule, nasal spray
Dosage: MDI -20mcg 2 inhs bid, SVN - 0.5mg qid
Onset: 15 minutes
Peak: 30-60 minutes
duration: 4-6 hours
COPD only

Question 4

Ipratropium and salbutamol

Answer 4

Combivent Respimat
SABA and SAMA
Available as: respimat, nebule
Dosage: 20mcg ipratropium + 100mcg salbutamol
Dosage nebule: 0.5mg ipratropium + 2.5mg albuterol
**combination is more effective in COPD than either agent alone

Question 5

Formoterol (1)

Answer 5

Foradil
LABA
Selective beta-2 antagonist
Available as: MDI
Dosage: 12mcg bid
Onset: 3 minutes
duration: up to 12 hours
Indication: Asthma and COPD

Question 6

Formoterol (2)

Answer 6

Oxeze
LABA
Selective beta-2 antagonist
Available as: turbuhaler
Dosage: 6 or 12mcg bid
Onset: 3 minutes
duration: up to 12 hours
Indication: Asthma only

Question 7

Salmeterol

Answer 7

Serevent
LABA
Available as: diskus
Dosage: 50mcg bid
Onset: 20 minutes
Peak: 3-5 hours
duration: 12 hours
Indication: Asthma and COPD

Question 8

Glycopyrronium

Answer 8

Seebri
LAMA
Available as: breezehaler
Dosage: 50mcg once daily
Indication: COPD only

Question 9

Aclidinium Bromide

Answer 9

Turdoza Genuair
LAMA
Potent agonist for all muscarinic receptors
Available as: MDI
Dosage: 400mcg bid

Indication: COPD only

Question 10

Umeclidinium Bromide

Answer 10

Incruse Ellipta
LAMA
Available as: DPI
Dosage: 62.5mcg once daily
Indication:
Potent antagonist for all muscarinic receptors

Question 11

Olodaterol

Answer 11

Striverdi
LABA
Available as: Soft Mist Inhaler (SMI)
Dosage: 2.5mcg once daily
duration: ultra long lasting - up to 24 hours
Indication: COPD maintenance

Question 12

Formoterol + Mometasone

Answer 12

Zenhale
LABA + ICS
Available as: MDI
Dosage: 100 or 200mcg mometasone with 5mcg formoterol bid
Onset: 20 minutes
Peak: 3-5 hours
duration: 12 hours
Indication: Asthma only

Question 13

Formoterol + Budesonide

Answer 13

Symbicort
LABA + ICS
Available as: DPI
Dosage: 100, 200 or 400mcg of budesonide + 6mcg or 12 mcg Formoterol
Onset: 3 minutes
duration: up to 12 hours
Indication: Asthma and COPD (more COPD)

Question 14

Salmeterol & Fluticasone (1)

Answer 14

Advair OR Wixela
LABA + ICS
Available as: DPI
Dosage - COPD:
100, 250 or 500mcg Fluticasone with 50mcg salmeterol bid
Dosage - Asthma:
125 or 250mcg Fluticasone with 25mcg Salmeterol
Onset: 20 minutes
Peak: 3-5 hours
duration: 12 hours
Indication: Asthma and COPD

Question 15

Vilanterol

Answer 15

LABA - not available as monotherapy, has to be given with an ICS
Indication: Asthma and COPD

Question 16

Fluticasone & Vilanterol

Answer 16

Breo Ellipta
LABA + ICS
Dosage: 100mcg fluticasone + 25mcg vilanterol (asthma may have 200mcg steroid dose) once daily
Duration: ultra long lasting -24 hours
Indication: Asthma and COPD

Question 17

Fluticasone & Umeclidium & Velanterol

Answer 17

Trelegy Ellipta
LABA + LAMA + ICS
(umeclidium = anticholinergic)
Dosage: 100mcg fluticasone + 62.5mcg umeclidium + 25mcg vilanterol once daily
(Steroid dose higher in asthma)
Duration: ultra long lasting - 24 hours
Indication: Asthma and COPD

Question 18

Indacterol

Answer 18

LABA - not available as monotherapy, has to be given with ICS
Indication: asthma only
B2-selective agonist in fixed combinations

Question 19

Mometasone & Indacterol

Answer 19

Atectura
LABA + ICS
Available as: breezhaler
Dosage: 80, 160 or 320mcg mometasone + 150mcg indacterol
once daily
Duration: ultra long lasting, 24 hours
Indication: Asthma

Question 20

Mometasone & Glycopyrronium & Indacterol

Answer 20

Enerzair breezhaler
LABA + LAMA + ICS
Available as: breezhaler
Dosage: 160mcg mometasone + 50mcg glycopyrronium + 150mcg indacterol
duration: ultra long lasting, 24 hours
Indication: Asthma

Question 21

Tiotropium Bromide & Olodaterol

Answer 21

Inspiolto Respimat
LAMA + LABA
Available as: SMI
Dosage: 2.5mcg tiopropium + 2.5mcg olodaterol once daily
Indication:

Question 22

Umeclidinium Bromide & Vilanterol

Answer 22

Anoro Ellipta
LAMA + LABA
Available as DPI
Dosage: 62.5 mcg umeclidinium + 25mcg vilanteral once daily
Indication:

Question 23

Aclidinium Bromide & Formoterol

Answer 23

Duaklir Genuair
LAMA + LABA
Available as:
Dosage:
Duration:
Indication: Asthma

Question 24

Glycoppyrolate bromide & Indacterol

Answer 24

Ultibro breezhaler
LAMA + LABA
Available as: DPI
Dosage: 50mcg Glycoppyrolate bromide + 110mcg indacterol once daily
Duration: 24 hours
Indication: COPD

Question 25

Budesonide, Glycopyrronium Bromide & Formoterol

Answer 25

Breztri Aerosphere
ICS + LAMA + LABA
Available as: MDI
Dosage: 182mcg budesonide + 8.2mcg glycopyrronium + 5.8mcg formoterol BID
Duration: 12 hours
Indication: COPD

Question 26

Tiotropium bromide

Answer 26

Spiriva
LAMA
M1 & M3 selectivity
Available as DPI or respimat
Dosage:
DPI - 18mcg once daily
Respimat (SMI) - 2.5mcg once daily
Indication: MDI for COPD, respimat for Asthma