S2 Fundamentals of the Assessment of Disorders of the Adrenal Gland

Question 1

How each cortical is stimulated ?

Answer 1

1. G by angiotensin II
2. F by ACTH
3. R by ACTH

Question 2

Which hormone have a negative feedback on ACTH ?

Answer 2

Cortisol

Question 3

What is the Circadian rhythm of cortisol secretion ?

Answer 3

It is diurnal rhythm that is :

1. Highest at morning
2. Lowest at night ( 75% less than morning )

Question 4

When the cortisol secretion normally peaks ?

Answer 4

1. 2 hours before being awake

2. Just when you wake up

Question 5

What is the difference between cushing syndrome and disease ?

Answer 5

1. Cushing syndrome ( include all types of cushing )
   - increase in cortisol
   - decrease in ACTH ( as -ve feedback )
2. Cushing disease
   - increase cortisol
   - increase ACTH

Question 6

What are the Clinical Features of Cushing’s Syndrome ?

Answer 6

• Spontaneous Bruising
• Proximal Myopathy
• Abdominal striae
• Central obesity w/ extremity wasting
• Dorsocervical fat pads (“Buffalo Hump”)
• Round facies (“Moon Facies”)
• Oligomenorrhea
• Osteoporosis