S18 Cardio biochemistry Lipoproteins

Question 1

components of lipid profile

Answer 1

total cholesterol
triglycerides
HDL-cholesterol
LDL-cholesterol
Non-HDL Cholesterol
Cholesterol/HDL Ratio

Question 2

LDL cholesterol calculation

Answer 2

Total cholesterol- HDL cholesterol- Griglycerides/5

Question 3

IDL

Answer 3

intermediate density lipoproteins.

return endogenous lipids to liver

Question 4

ApoA’s are found in

Answer 4

chylomicrons and HDL

Question 5

Chylomicrons have

Answer 5

ApoB48

Question 6

LDL has

Answer 6

ApoB100

Question 7

ApoC are associated

Answer 7

with all classes

Question 8

ApoE is associated with

Answer 8

older remnant lipoproteins and all classes

Question 9

High cholesterol

Answer 9

LDL over 150 mg/dl

Total Cholesterol above 240 mg/dl

Question 10

Niemann-pick type C disease

Answer 10

Cholesterol not released fro lysosome

cholesterol accumulates

cells die (nerve cells), early death

Question 11

HDL is taken up by the

Answer 11

SR-B1 receptor (on many cells) or the HDL receptor (mainly liver)

Question 12

HDL requires two enzymes

Answer 12

LCAT (lecithin cholesterol acyl-transferase) helper enzyme esterifies cholesterol, and secures cholesterol for transport.

CETP exchanges cholesterol esters for triglycerices between HDL and VLDL.

Question 13

Lp(a)

Answer 13

may interfere with break down of clots, inhibiting the fibrolytic activity of plasminogen