Rx-Rx Interaction

Question 1

What are pharmacokinetic interactions?

Answer 1

When the delivery of the object drug to its site of action is altered by the precipitant drug.

*Amount of drug in blood is altered by affecting absorption (speeds, slows, increases, decreases)

Question 2

What are pharmacodynamic interactions?

Answer 2

When the response of the object drug is modified by the precipitant drug without changes in drug concentrations.

*Amount of drug in blood remains the same but its effect is altered

Question 3

What are pharmaceutic interactions?

Answer 3

They are physical or chemical incompatabilities

Question 4

What is an additive interaction?

Answer 4

The combined effect of two drugs is equal to the sum of the effect of each drug given alone

Question 5

What is a synergistic interaction?

Answer 5

When the combined effect exceeds the sum of the effects of each drug given alone

Question 6

What is a potentiation reaction?

Answer 6

It is the creation of a toxic effect from one drug due to the presence of another drug

Question 7

What is an antagonism interaction?

Answer 7

Interference of one drug with another (e.g. Rifampin and everything)

Question 8

What is an object drug and a precipitant drug?

Answer 8

Object drug aka effect of a drug as a result of co-administration of another drug known as the precipitant drug