RX 260 Flashcards

1
Q
  • Symptoms of menopause

- Endometrial hyperplasia and carcinoma (polyp due to pro-estrogen effect in endometrium…weird)

A

Tamoxifen ADRs

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2
Q

Metronidazole ADRs (below diaphragm while Clinda is above)

A
  • Rash, UTICARIA, YELLOW discoloration of the skin
  • OPTIC NERVE DAMAGE
  • N/V, dizziness, HA
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3
Q

Vancomycin ADRs

A
  • “Red man syndrome”
  • PHELBITIS
  • Nephrotoxicity and ototoxicity
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4
Q

Ceftriaxone ADRs

A

-Elevated liver enzymes
-Pseudomembranous colitis
-Nephrotoxicity
(Hypersensitivity rxns, diarrhea, nausea)

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5
Q

Albuminocytologic dissociation (elevated protein, normal WBC count)

A

-Characteristic of GUILLAIN-BARRE syndrome

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6
Q

Stages of Shock: Class II

A

Blood loss: 15-30%
HR: Increased
BP: Normal
CNS symptoms: Anxious

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7
Q

Stages of Shock: Class IV

A

Blood loss: >40%
HR: Increased
BP: Decreased
CNS symptoms: Lethargic

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8
Q

Stages of Shock: Class III

A

Blood loss: 30-40%
HR: Increased
BP: Decreased
CNS symptoms: Confused

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9
Q
  • Tachycardia one of earliest symptoms
  • Sympathetic activation: vasoconstriction, cool mottled skin, hypothermia, acidosis, and diversion of blood from organs (like kidneys)
A

Hemorrhagic shock

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10
Q

Parinaud syndrome

A
  • Pressure on pretectal region of midbrain

- Vertical gaze and pupil abnormalities

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11
Q

Enlarged adenoids and Morning headaches…

A

Sleep apnea in children

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12
Q

Pineoblastomas

A
  • ICP due to OBSTUCTION OF CSF FLOW (main presenting symptom)
  • May produce excess melatonin
  • Pineal mass btw thalamic bodies
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13
Q

Diabetic Ketoacidosis

A
  • Insulin deficiency and increase in glucagon
  • Liver generates ketones
  • Hyperglycemia osmotic diuresis→volume depletion→POLYDIPSIA and POLYURIA
  • Hyperkalemia slash overall total body K+ deficit
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14
Q

Pseudohyponatremia

A
  • Serum sodium is low but urine excretion of Na+ not increased
  • Ex: Hyperglycemia→osmotic shift that pulls fluid from cells into the blood stream→Increase in fluid makes serum Na+ seem low but it really is the same
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15
Q

Clozapine (atypical) MOA and ADR (4)

A
  • Blocks 5-HT and dopamine receptors
  • AGRANULOCYTOSIS→severe reduction in WBC (WEEKLY blood monitoring for WBC count)
  • Weight GAIN
  • Seizures
  • QT prolongation
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16
Q

Fluphenazine (typical) ADR

A
  • Extrapyramidal
  • Hyerprolactinemia and galactorrhea
  • Anti-muscarinic effects (dry mouth, etc)
  • QT PROLONGATION
17
Q
  • Galactorrhea (increased prolactin) → unique from other Atypicals
  • FERTILITY problems (dysregulation of LH and FSH)
A

Risperidone (atypical) ADR

18
Q

Meniere Disease Triad: (idiopathic disorder)

A

1) Low-frequency Sensorineural hearing loss (progressive)
2) Vertigo
3) Tinnitus
Aural fullness also
Malfunction of endolymphatic sac→filtration and excretion of endolymph

19
Q

30-60 year olds with episodes of vertigo that last for hours
Increase in the volume (increased production or decreased excretion of endolymph) of the endolymphatic system (hydrops)
Fluid contained in membranous labyrinth of the inner ear
*Malfunction of endolymphatic sac→filtration and excretion of endolymph

A

Meniere Disease Causes

20
Q

BBPV (benign paroxysmal positional vertigo)

A
  • Vertiginous symptoms (last seconds)

- Freely moving crystals of calcium carbonate w/in semicircular canals

21
Q

1) Low-frequency Sensorineural hearing loss (progressive)
2) Vertigo
3) Tinnitus
Aural fullness also
Malfunction of endolymphatic sac→filtration and excretion of endolymph

A

Meniere Disease Triad: (idiopathic disorder)

22
Q

Vestibulocochlear nerve (CNVIII) damage

A
  • SENSORINEURAL hearing loss (may have equilibrium disturbances)
  • Hearing loss in HIGH-FREQUENCY RANGE
  • Problems with speech discrimination
23
Q

Presbycusis

A
  • Age related hearing loss

- HIGH-FREQUENCY HEARING LOSS

24
Q

Primary stimulus for insulin secretion (and others)

A

Hyperglycemia

Others: increase in FA or AA in blood, cortisol, GH, Gastrointestinal inhibitory peptide

25
Q

CO= SV X HR; how can you solve for CO? SV?

A

1) CO= MAP/TPR
2) CO=(Rate of O2 consumption)/ (arterial O2- venous O2)
3) SV= EDV- ESV

26
Q

Epidermolysis Bullosa mutations in…

A

Keratin genes

27
Q

Loop or thiazides cause hypokalemia and Hypocalcemia

A

LOOP

28
Q

Chlordiazepoxide

A

Long-acting benzodiazepine

Management of alcohol withdraw

29
Q

Benzodiazepine overdose

A

Flumazenil (antagonist of benzodiazepine receptors)

30
Q
  • Ipsilateral deficits
  • Loss of coordination (ataxia)
  • HYPOTONIA
  • Intention tremor
  • Instability→ fall to side of lesion
A

Cerebellar lesions

31
Q
  • Inhibitor of alcohol dehydrogenase
  • Prevent conversion of ethylene glycol→oxalic acid (toxic)
  • Prevent conversion of methanol→formic acid (toxic)
  • Antidote for methanol poisoning (can lead to blindness)
  • Antidote for ethylene glycol (can lead to kidney failure)
A

Fomepizole

32
Q

Anterior spinal arteries arise from…

A

Vertebral arteries→arise from subclavian arteries

33
Q
  • Fine-tuning and motor activities (force control and timing)
  • Unilateral lesion→ minor motor (not ataxia) problems in contralateral limbs
A

Basal ganglia lesion