RSI Medications Flashcards
Rocuronium Class
Neuro-Muscular Blocking Agent for paralysis
Suxamthonium Class
Neuro-Muscular Blocking Agent for paralysis
Fentanyl Class
Opioid (synthetic) Analgesic
Morphine Class
Opioid Analgesic
Midazolam Class
Benzodiazepine
Ketamine Class
General Anaesthetic
Propofol Class
General Anaesthetic
Fentanyl MOA
Binds to opioid receptors, results in hyperpolarisation of cells and inhibiition of nerves leading to reduced pain
Morphine MOA
Binds to mu-receptors of CNS and PNS, inhibits nocieceptive receptors reducing transmisson that reduces pain
Propofol MOA
Inhibits GABBA
Ketamine MOA
Interacts with NMDA, muscarinic, monoaminergic, opioid, voltage gated Ca receptors in brain producing dissociative/sedative state.
Midazolam
Acts on GABBA receptors, increasing activity that increases chloride channel opening producing muscle relaxation/anaesthesia
Suxamethonium MOA
Depolarising NMBA. Prolonged depolarisation of muscles to a membrane potential above what an action potential can be triggered. Causes vesiculations.
Rocuronium
Non-depolarising NMBA. Inhibits neuromuscular transmission by blocking acetylcholine at synaptic terminals preventing depolarization and muscle contraction
Fentanyl duration and half life
Onset 60seconds
Peaks 2-5minutes
Duration 30-60minutes
Half life 90minutes