RSI Drugs

Question 1

Propofol dose/ onset/ duration

Answer 1

Neat- 1000mg/100ml-> 10mg/ml
Induction 1-2mg/kg
Maintenance- 1.5-3mg/kg/hr
Bolus- 10-50 mg or 1-5 ml
Onset IV 40 seconds
Duration- 3-5 mins

Question 2

Propofol adverse effects

Answer 2

Respiratory depression
Aponeas
Hypotension
Hypertonicity
Myoclonus tics

Question 3

What is propofol infusion syndrome

Answer 3

Cause by high dose or high cumulative dose
- bradycardia
- RAGMA
- Rhabdomyolysis
- raised LFTs/ fatty liver
- hyperlipidemia

Question 4

Ketamine - dose/ onset/ duration and bolus

Answer 4

Neat- 200mg/2ml—> dilute 200mg in 20ml saline for 10mg/ml
Induction 1-2mg/ ml (10-20ml)
Adult 100-200mg
Maintence- 50-100mg/hr run at 4mg/ml/min
Bolus 8-20mg (2-5ml)
IV onset 30-60 secs IM 3-8 mins
IV duration 5-15 mins IM 10-30 mins

Question 5

Fentanyl- induction/ maintenance/Bolus onset and durations

Answer 5

Comes as 100mcg in 2ml or 500mcg in 10ml
Dilute 100mcg in 10ml saline= 10mcg/ml
Dose
Premed- 0.5-1mcg/kg (25-100mcg)
Induction- 2-3mcg/kg (150-300mcg)
Maintenance- 10mcg/ ml at 10-200mcg/hr or 1-20ml per hour
Bolus- 25-50mg
IV onset 1-2 mins
Duration- 30-40 mins

Question 6

Midazolam dose/ induction/ infusion/ Bolus/ onset and duration

Answer 6

Found at 1mg/ml—> dilute 50mg in 50ml saline so 1mg/ml
Sedation 1-2mg/kg IV
Bolus 2.5-5mg IV (2.5-5ml)
Maintenance- 1-20mg/hr
Onset IV- 2 mins
IM/PR/PO- 15 mins
Dose IV/ IM 0.15mg/kg PR 0.3mg/kg