RS6 Gas Transport

Question 1

Systemic oxygen transport equation

Answer 1

SO = cardiac output x PaO2

Question 2

What are the 2 forms of oxygen in artery

Answer 2

Oxygen dissolved in plasma
Oxygen bound to hemoglobin in RBC

Question 3

Henry’s Law

Answer 3

The quantity of a gas that will dissolve in a liquid is proportional to the partial pressure of the gas and its solubility

Question 4

For each mmHG PO2 there is ____mlO2 dissolved in plasma per 100mL of blood. What does this means?

Answer 4

0.003
Very little oxygen dissolved in plasma

Question 5

What are the 2 main components of Hemoglobin?

Answer 5

4 iron-containing heme groups - site of O2
Globin portion consisting of 4 polypeptide chains 2 beta and 2 alpha - site of CO2 binding

Question 6

During exercise, O2 saturation is ___ than during rest

Answer 6

less
35 vs 75

Question 7

Bohr effect

Answer 7

A right shift of the oxygen-hemoglobin dissociation resulting from an increase in PCO2

Question 8

Transport of CO2 has a profound effect on

Answer 8

the acid-base status of the blood

Question 9

By altering ____ and thus the elimination of CO2, the body has great control over its _______ balance

Answer 9

ventilation, acid base

Question 10

Haldane effect

Answer 10

A left shift in the CO2 dissociation resulting from a decrease in PO2

Question 11

Nonvolatile acids (fixed or metabolic acids)

Answer 11

Excreted by the kidneys
Produced in the body from sources other than carbon
Lactic acid

Question 12

Peripheral chemoreceptors sense
Found in __

Answer 12

PaO2
Carotid, aorta

Question 13

Central Chemoreceptors sense

Answer 13

changes in PH

Question 14

Does the carotic body nerve play a role in min-min-changes?

Answer 14

little role for big changes

Question 15

What is the functional significance of the chemoreceptor pattern?

Answer 15

Above 60 PO2 we don’t see a large saturation change because hemoglobin is saturared

Question 16

What is the primary driver of normal respiratory patterns?

Answer 16

PCO2

Question 17

What are the 3 receptors in the lung?

Answer 17

Pulmonary stretch receptors
Irritant receptors
J receptors

Question 18

What is the pattern generator in the control of ventilation?

Answer 18

Pre-botzinger complex

Question 19

Although the ____ alone can generate a basic respiratory rhythm, both ____ centers and inputs fine-tune this rhythm

Answer 19

medulla, higher CNS

Question 20

THe diaphragm is innervated by the

Answer 20

phrenic nerve

Question 21

What was the conventional view of action?What was it based upon?

Answer 21

External - insp
Internal - Exp
Hamberger

Question 22

What is the correct view? from recent studies in dogs and humans by ____-

Answer 22

DeTroyer A et al
External = insp dorsal and rostral intercostals
Internal = intercostals ventral and caudal