RRT Flashcards

1
Q

When do you start dialysis?

A
AEIOU
•	Acidosis
•	Electrolyte imbalance (hyperkalaemia)
•	Intoxication
•	Overloaded with fluid
•	Uraemic encephalopathy/pericarditis
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2
Q

What toxins can be removed with dialysis?

A
SLIME
o	Salicylic acid
o	Lithium
o	Isopropanol
o	Magnesium-containing laxatives
o	Ethylene glycol
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3
Q

How many times is HD done per week?

A

4hrs 3X/week

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4
Q

How is HD connected to the body?

A

HD line or AV fistula

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5
Q

What is a HD line?

A

o Tube inserted into subclavian or jugular vein with a tip that sits in the SVC or RA

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6
Q

What is an AV fistula?

A

o Artificial connection between an artery and vein

o Takes 3 months to mature

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7
Q

When examining a fistula, what do you look for?

A
  • Skin integrity
  • Aneurysms
  • Palpable thrill (pulsation = problem with fistula outflow)
  • Machinery murmur
  • Previous fistula (look at the other arm)
  • Recent use? -> dressing, needle sites
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8
Q

What are the complications of a HD line?

A
  • Infection

- Blood clots

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9
Q

What are the complications of an AV fistula?

A
  • Aneurysm
  • Infection
  • Thrombosis
  • Stenosis
  • STEAL syndrome
  • High-output HF
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10
Q

What causes STEAL syndrome?

A
  • Inadequate blood flow to the limb distal to the AV fistula causing distal ischaemia
  • Blue/cold hands
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11
Q

What causes high-output HF?

A

• Blood flows quickly from arterial to venous system causing a rapid return of blood to the heart

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12
Q

What is PD?

A

Uses peritoneal membrane as a filtration membrane. Ultrafiltration occurs from the blood, across the peritoneal membrane and into the dialysis solution. Dialysis solution is then replaced.

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13
Q

What are the types of PD?

A

• Continuous ambulatory PD (CAPD) 4X/day -> Dialysis solution in peritoneum at all times
• Automated PD (APD) -> happens at night
Complications:

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14
Q

What are the complications of PD?

A
  • Bacterial peritonitis
  • Peritoneal sclerosis
  • Ultrafiltration failure
  • Weight gain
  • Psychosocial effects
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15
Q

What are the complications of RRT?

A
  • CVD
  • Protein-calorie malnutrition
  • Renal bone disease
  • Infection
  • Amyloid
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16
Q

What is the best treatment option for ESRD?

A

Renal transplant

17
Q

What is tacrolimus?

A

Calcineurin inhibitors

- Inhibit T-cell activation and proliferation

18
Q

What affects tacrolimus metabolism?

A

Affected by drugs that impact CP450 as clearance is dependent upon CP450
- Macrolides and antifungals

19
Q

What are the side effects of tacrolimus?

A
  • Hyperlipidaemia
  • HTN
  • Hyperglycaemia
20
Q

What is the mechanism of action of Mycophenolate mofetil (MMF)?

A

o Blocks purine synthesis by inhibition of IMPDH

o Inhibits proliferation of B and T cells

21
Q

What is the mechanism of action of Azathioprine?

A

o Inhibits purine synthesis

22
Q

What are the side effects of azathioprine?

A
  • Bone marrow depression
  • Nausea/vomiting
  • Pancreatitis
  • Non-melanoma skin cancer
23
Q

What happens if azathioprine and allopurinol are given together?

A

o Pancytopenia (low RBCs, WBCs and platelets)