Routes of Administration Intro

Question 1

What are the dosage form reuirements?

Answer 1

• Reproducible performance
• acceptable to the patient
• Large Scale Production
• Reproducible Quality
• Physically and chemically stable
• Preservation

Question 2

What information helps design a dosage form?

Answer 2

• A new drug substance
• Therapeutics Consideration
• Biopharmaceutical considerations (ADME)
• Routes; oral, parenteral, topical, rectal, respiratory, nasal, eye, ear

Question 3

What are the Pros of using the Oral Route?

Answer 3

• Swallowing an immediate tablet
• Most common and simple
• Modified release
• High surface area
• Good blood supply

Question 4

What are the cons of using the Oral Route?

Answer 4

• Lag time
• Hostile enviroment (pH, Enzymes)
• Variability - Chronopharmaceutics
• First pass metabolism
  -Difficult to reverse therapy
• Irritation to gastro-intestinal System

Question 5

Describe the Solid Dosage formulation?

Answer 5

• Capsules
• Drug enclosed in a small gelatin shell
• can be hard or soft?
• hard gelatin more commonly used
• soft gelatin used for encapsulating liquids
• useful drugs that are poorly released from tablets

Question 6

What are the three main parenteral routes?

Answer 6

• Subcutaneous
• Intramuscular
• Intravenous