Routes of Administration II

Question 1

When do oral drugs work?

Answer 1

If it survives stomach acid, enzyme attack, absorption across GI membrane, survive liver

Question 2

What types of chemical modifications cause a drug to become inactive?

Answer 2

Ester hydrolysis, low pH catalysis, ester breakage

Question 3

What type of delivery can be obtained by oral ROA?

Answer 3

Systemic or local delivery

Question 4

Where does oral drug delivery travel?

Answer 4

Passage through stomach and intestine

Pyloric sphincter tightens at base of stomach so drug stays until broken down

Question 5

How do oral drugs travel through the body?

Answer 5

Gastric emptying, eating, peristaltic movement of GI - Motility

Question 6

What does oral drug delivery provide?

Answer 6

Many barriers for drug absorption eg mucus and SI walls

Question 7

What types of transport occur for oral delivery?

Answer 7

Passive, carrier-mediated and specialised absorption

Question 8

What are the advantages of oral drug delivery?

Answer 8

Common, accepted, safe
Economical (cheap)
Self-administration
Slow release for extension