Rôles molécules d'adhésion PNN Flashcards

1
Q

ICAM

A

reconnaissance

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2
Q

intégrines

A

modif du cytosquelettes

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3
Q

sélectine

A

diapédèse

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4
Q

superfamille du récepteur du TNF

A

apoptose

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5
Q

prot TM de type III

A

activation

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6
Q

durée PNN

A

10j
6-12h
1-3j

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7
Q

durée PNE

A

3-6j
8-12h
7-10j

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8
Q

durée PNB

A

7j
3-4j
?

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9
Q

durée monocyte

A

1-2j
2-3j
plusieurs semaines

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10
Q

numération PNN

A
40-75%
1.5-7G
<1.5 = neutropénie 
< 0.5 agranulocytose 
>7= neutrophilie
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11
Q

numération PNE

A

1-5%
0.5 G
hyperéosinophilie > 0.5

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12
Q

numération PNB

A

< 1%

0.05 G > basophilie

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13
Q

numération monocyte

A

2-10%
0.1-1 G
1 G > monocytose

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14
Q

nom monocytes dans le foie

A

cellules de Küpffer

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15
Q

nom monocytes dans l’épiderme

A

cellules de Langerhans

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16
Q

nom monocytes dans l’os

A

ostéoclastes

17
Q

nom monocytes dans le cerveau

A

microglie

18
Q

nom monocytes dans les ganglions / rate

A

cellules dendritiques

19
Q

CD PNN

A

CD 45 = panleucocytaires

CD11b / CD13 / CD15

20
Q

CD monocytes

A

CD14 + récepteurs au LPS donnant la capacité de capture des bactéries à GRAM négatif

21
Q

CD cellules NK

A

CD 56 + CD16 mais pas CD3

22
Q

stade granulations primaire PNN

A

myéloblaste

23
Q

stade granulation secondaires PNN

A

myélocyte

24
Q

granulation PNE

A

forme cristalloïde MBP = 50% du cristalloïde et Lypophospholipase  formation de cristaux de CharcotLeyden dans le milieu extracellulaire
Autres enzymes : héparinases/ histaminases/ peroxydases

25
Q

granulation monocytes

A
  • Myélopéroxydase
  • Lysozyme
  • Estérases
26
Q

granulations NK

A

granzyme perforine