ROCA Sept 2018 Flashcards
a) What factors determine the intraocular pressure in a healthy eye?
- Arterial blood pressure
- Venous pressure
- Partial pressures of PO2 and PaCO2
- Partial pressures
b) What key points would you need to know when assessing this patient preoperatively?
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1. Fasting time
- RTA - cause? Medical cause underlying crash
ECG - Other injuries
Any life threatening injuries that require Rx prior to eye - Airway assessment
- Other significant PMH / Prev anaesthetic
C. The patient requires urgent surgery. Discuss your specific intraoperative management.
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d) What contraindications are there to performing a regional block in elective ophthalmic surgery?
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e) What different types of regional block are suitable for ophthalmic surgery?
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a) List the postoperative pulmonary complications that may occur following non-cardiothoracic surgery
Atelectasis Pneumonia Respiratory failure Pleural effusion Pneumothorax Bronchospasm Aspiration pneumonitis
b) What are the patient related risk factors for postoperative pulmonary complications following non cardiothoracic surgery?
Age >60 years (good) (good)
American college of anaesthesiologists II or more (good)
Functional dependency (good) Congestive heart failure (good) Chronic obstructive pulmonary disease (good)
Smoking (fair)
Recent upper respiratory tract infection (fair)
Pulmonary hypertension (fair)
Delirium (fair)
Alcohol use (fair)
Weight loss >10% (fair)
Disseminated cancer (fair)
b Surgery related risk factors for postoperative pulmonary complications following non cardiothoracic surgery?
Prolonged surgery (>3 h)
Surgical site: Abdominal, thoracic, neurosurgery, vascular, head and neck surgery (good)
Emergency surgery (good)
c) How might anaesthesia contribute to postoperative pulmonary complications?
- General > Regional
The combination of general anaesthesia, supine
positioning, opiates, and residual neuromuscular block reduces lung volumes and causes atelectasis in a spontaneously ventilating patient.
Poor use of Neuromuscular blocking agents (NMBAs), by failure to monitor correctly or excessive dosing, is associated with an increased risk of PPC
Anaesthetic agents diminish respiratory drive and the response to hypoxia and hypercapnia, resulting in hypoventilation. In a spontaneously ventilating patient, the closing capacity approaches FRC and the small airways collapse causing atelectasis in the dependent regions of the lung.
Hypoxaemia can result from ventilation–perfusion mismatching and increased shunt fraction. Prolonged periods of 100% oxygen may produce absorption atelectasis as all the oxygen is absorbed and the
splinting effect of nitrogen in the alveoli is lost.
Inadequate analgesia
The
effects of anaesthesia, bed rest, and opioids inhibit the cough
reflex and impair respiratory tract ciliary activity, while dry
gases result in mucus plugging. These physiological effects contribute to the development of PPCs.
What perioperative strategies may you adopt to reduce postoperative pulmonary complications?
Preoperative
Optimization of existing cardiorespiratory disease (fair)
Early smoking cessation (fair)
Prehabilitation exercise programmes (insufficient data)
Intraoperative:
Minimally invasive surgical Techniques (fair)
Lung-protective ventilationvstrategies (fair)
Selective use of nasogastric tubes (good)
Short acting NMBAs with quantitative monitoring
(fair)
Neuraxial blockade (insufficient data) Goal-directed fluid therapy (insufficient data)
Postoperative Adequate analgesia (good) Early mobilization (good) Postoperative epidural analgesia (insufficient) Lung expansion techniques (good)
What is Guillain–Barré?
What is Guillain–Barré?
» Acute, immune-mediated, pre-junctional, ascending demyelinating
polyneuropathy affecting sensory, motor and autonomic nerves.
What are causes of Guillain Barre?
> > Associated with respiratory
or gastrointestinal infection
(especially Campylobacter) in preceding weeks.
> > Autoimmune in nature –
antibodies attack the myelin sheath
or, more rarely, the axon itself.
b) What are the clinical features of Guillain–Barré syndrome? (6 marks)
1 Variable presentation depending on subtype;
different forms associated with immune attack on different parts of the neurone.
Recovery is variable,
ranging from full recovery
to relapsing, remitting form.
2 >> Motor: typically ascending symmetrical weakness (flaccid, areflexic paralysis), may ascend to involve respiratory muscles and also to cause facial nerve palsies with bulbar weakness and opthalmoplegia.
> > Sensory:
ascending sensory impairment
associated with pain.
> > Autonomic: arrhythmias,
labile BP, urinary retention,
paralytic ileus,
hyperhydrosis, sudden death.
> > Miller Fisher syndrome:
this is a variant typified by ataxia, areflexia,
opthalmoplegia +/− weakness.
d) What are the specific considerations when anaesthetising a patient recovering from Guillain–Barré syndrome?
Airway:
» Bulbar weakness,
poor cough, increased risk of aspiration.
Intubation required – consider need for rapid sequence induction.
> > May still have tracheostomy in situ
if still requiring ventilatory support or
assistance with secretion clearance.
Respiratory:
» Increased risk of pneumonia
secondary to aspiration and poor ventilatory
function. Make full assessment of this – history, nature of secretions, temperature, chest auscultation. Treat as required, delay non-urgent surgery if necessary.
> > Significantly reduced ventilatory capacity,
assess likelihood of requiring
noninvasive or invasive ventilation postoperatively.
d) What are the specific considerations when anaesthetising a patient recovering from Guillain–Barré syndrome?
Cardiovascular:
» Autonomic instability, labile BP (with sensitivity to commonly used vasoactive drugs),
risk of arrhythmia.
Invasive monitoring indicated including cardiac output monitoring to guide fluid administration (ensure
full circulation as dehydration will exacerbate lability).
> > Prolonged illness,
multiple cannulations, access may be tricky.
Neurological:
» Neuropathic pain common –
may already be on antineuropathic drugs
+/− opioid analgesia.
Need to plan postoperative pain relief,
involve acute Cardiovascular:
» Autonomic instability, labile BP (with sensitivity to commonly used
vasoactive drugs), risk of arrhythmia. Invasive monitoring indicated
including cardiac output monitoring to guide fluid administration (ensure
full circulation as dehydration will exacerbate lability).
» Prolonged illness, multiple cannulations, access may be tricky.
Neurological:
» Neuropathic pain common – may already be on antineuropathic drugs
+/− opioid analgesia. Need to plan postoperative pain relief, involve acute
d) What are the specific considerations when anaesthetising a patient recovering from Guillain–Barré syndrome?
Pharmacology:
» Suxamethonium: contraindicated due to risk of hyperkalaemia following
the development of extrajunctional nicotinic receptors.
> > Non-depolarising neuromuscular blocking agents: increased sensitivity – reduce dose.
> > Opioids: increased sensitivity to respiratory depressant effect in the presence of existing respiratory compromise, may already be taking
opioids and so dose adjustments may be necessary.
d) What are the specific considerations when anaesthetising a patient recovering from Guillain–Barré syndrome?
Haematology:
» Risk of deep vein thrombosis due to prolonged immobility – continuation
of thromboembolic deterrent stockings and pneumatic compression
devices and pharmacological prophylaxis (check timing if planning
neuraxial technique).
Cutaneomusculoskeletal:
» Prolonged illness may be associated with weight loss – care with positioning and padding.
Renal:
» Check renal function – may dictate drug choices.