RNA-Based Gene Regulation Flashcards
1
Q
mRNA lifespans
range from .
A
less than an hour to about 24 hour
2
Q
mRNA are checked by
A
quality control (degraded)
3
Q
mRNA decay happens through
A
- deadenylation of polyA tail
- exonucleolytic degradation in exosome
4
Q
majority of mRNAs are unstable due to — that are present in the mRNA
A
cis-acting sequences
5
Q
— (RNA-binding proteins) can stabilize mRNAs
A
trans-acting factors
6
Q
what is the exosome?
A
10 protein complex that has RNA-binding activity and 3’-5’ exonuclease activity
7
Q
Where does mRNA decay occur?
A
cellular foci called mRNA processing bodies (P-bodies) -> usually 5’-3’ in P-bodies bc decapped
