Rickettsia Flashcards

1
Q

What causes rocky mountain spotted feiver?

A

Rickettsia ricketsii

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2
Q

What are the clinical presentations of RMSF

A

High fever
Severe HA
Macular rash on extremities that evolves to flat discoloration -> petechial rash

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3
Q

How long is the incubation period for RMSF?

A

Up to 2 weeks

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4
Q

What is the vector for transmission for RMSF?

A

Prolonged contact with Ticks- transovarian transmission between ticks as well

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5
Q

How is RMSF diagnosed?

A

Clinical sx, epidemiology + MIF positive results

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6
Q

How is RMSF treated?

A

Tetracycline, fluoroquinolones

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7
Q

Can you use chloramphenicol for RMSF?

A

Not recommended due to higher relapse rate

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8
Q

What happens if treatment of RMSF is delayed or untreated?

A

Delayed treatment: increased chance of death

10-25% mortaliity if untreated

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9
Q

Is there a vaccine for RMSF?

A

No

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10
Q

What causes Rickettsialpox?

A

Rickettsia Akari

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11
Q

What is the clinical presentation of Rickettsialpox?

A

Mild disease with vesicular rash

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12
Q

What is phase 1 of rickettsialpox?

A

Firm red papule at bite site -> becomes vesicle-> then black eschar as bacteria spreads

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13
Q

What is phase 2 of rickettsialpox?

A

@9-14 days
High fever, severe HA, chills/sweat,s myalgias, photophobia, vesicular rash

Self limiting after 1 week

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14
Q

What is the transmission vector for rickettsialpox?

A

Bloodsucking mites

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15
Q

Is rickettsial pox lethal?

A

No, it is self limiting after 1 week

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16
Q

What causes epidemic typhus?

A

Rickettsia Prowazekii

17
Q

What is the clinical presentation of Epidemic Typhus?

A

Fever, HA, myalgia 1-2 weeks after exposure

Maculopapular rash -> first trunk then spreads to extremities

18
Q

Which demographic of patients is epidemic typhus more fatal in?

A

> 40 patients; older

19
Q

How is epidemic typhus transmitted?

A

Lice - present in their feces

Gets in when host scratches and breaks into skin

20
Q

How is epidemic typhus diagnosed?

A

MIF positive test

21
Q

How is epidemic typhus treated?

A

Tetracycline or chloramphenicol

22
Q

Is there a vaccine for epidemic typhus?

A

Yes for high risk population

23
Q

What is Brill-Zinsser?

A

Relapse of louse borne typhus - appears 10-40 years after first attack

Milder and less fatal

24
Q

What is the primary reservoir for R.Prowazekii?

A

Humans

25
Q

What causes murine typhus?

A

Rickettsia Typhi

26
Q

What is the clinical presentation of murine typhus?

A

Abrupt fever, severe HA, chills, nause, myalgia

LATE maculopapular rash on trunk

27
Q

What are the transmission vectors for murine typhus?

A

Flea

28
Q

What is used to treat murine typhus?

A

Tetracycline
Doxycycline
Chloramphenicol