Rheumatology7-11

Question 1

Which antibodies are the most specific for rheumatoid arthritis?

Answer 1

citrullinated peptides/proteins

*Rheumatoid factors (RF), antibodies against the Fc portion of IgG are found in 80% of RA patients, but also 10% of healthy individuals 30% of SLE patients, nearly all mixed cryoglobulinemia patients and some other inflammatoroy conditions.