Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

BPT Rheumatology > Rheumatology Revision > Flashcards

Rheumatology Revision Flashcards

1
Q

What are the antibodies of SLE?

A

ANA, dsDNA, anti-Sm, anti-histone (drug-induced)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What can be used as a marker of disesase activity in lupus?

A

dsDNA, C3/C4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the most specific antibody for SLE?

A

anti-Sm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the antibodies of sjogren’s

A

ANA, Ro, La

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What antibodies are in mixed connective tissues disease?

A

anti RNP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What antibodies are in scleroderma?

A

ANA, anti Scl-70 (diffuse), anti centromere (limited), RNA polymerase III (renal crisis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What antibodies are in myositis?

A

ANA, anti Jo1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What test should be ordered in statin induced necrotising myopathy?

A

anti-HMG co-A reductase antibodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What antibodies are in RA?

A

RF, anti CCP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Are RF and anti CCP markers of disease activity in RA?

A

No

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What antibodies are in ANCA associated vasculitis?

A

ANCA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the three types of ANCA associated vasculitis?

A

granulomatosis with polyangitis, microscopic polyangits, eosinophilic granulomatosis with polyangitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which ANCA subtype is associated with GPA?

A

PR3 antibodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which ANCA subtype is associated with MPA?

A

MPO antibodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which ANCA subtype is associated with EGPA?

A

MPO and PR3 antibodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Should ANA ever be repeated?

A

No

17
Q

What is a DMARD?

A

a disease modifying anti rheumatic drug

18
Q

What are the common conventional synthetic DMARDs?

A

methotrexate, sulfasalazine, hydroxychloroquine, leflunomide, azathioprine

19
Q

What is the mechanism of action of methotrexate?

A

purine metabolism inhibitor

20
Q

What are the common side effects of methotrexate?

A

GI upset, fatigue, mental clouding, mouth ulcers, hair thinning, low blood counts, abnormal LFTs, pneumonitis

21
Q

Why do you need to check UECs in methotrexate?

A

because it is renally cleared, but it is not renal toxic

22
Q

What medication should be avoided when on methotrexate?

A

trimethoprim

23
Q

How do you minimise GI SEs of sulfasalazine?

A

start slow

24
Q

What are the SEs of sulsasalazine?

A

headaches, GI upset, orange discolourtation of urine/sweat, low blood counts, abnormal LFTs

25
Q

What are the SEs of hydroxychloroquine?

A

GI side effects, increased sensitibity to sun, blurred vision, worse psoriasis, retinal toxicity

26
Q

How often should patients on hydroxychloroquine get an opthalmology review?

A

every 12-18 months

27
Q

What are the SEs of leflunomide?

A

diarrhoea, dry mouth, mouth ulcers, hair thinning, HTN, dizziness, low blood count, abnormal LFTs, pneumonitis, peripheral neuropathy, shingles

28
Q

What test should be done in all patients before starting a DMARD?

A

quantiferon gold and CXR, Hep B, Hep C, HIV

29
Q

What vaccinations are recommended while on DMARDs?

A

pneumovax, fluvax and to have any live vaccines required before starting

30
Q

Which rheumatic medications can be used in pregnancy?

A

glucocorticoids, azathioprine, cyclosporine, tacrolimus, sulfasalazine, anti TNFs, IVIG

31
Q

Which rheumatic medications cant be used in pregnancy?

A

cyclophosphamide, methotrexate, mycophenolate, leflunomide, NSAIDs

32
Q

What should be done if someone accidentally conceives while on methotrexate?

A

cease and continue 5mg folate throughout pregnancy

33
Q

Can biologics be used in pregnancy?

A

TNF inhibitors are safe however others should be ceased

34
Q

What needs to be done about DMARDs in perioperative management?

A

csDMARDs can continue but biologics need to be stopped

35
Q

What should be done for SLE in perioperative management?

A

If not severe SLE stop 1/52 prior to surgery

BPT Rheumatology (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions