Rheumatology - random topics

Question 1

bullous disease with mucosal involvement

Answer 1

pemphigous vulgaris

Question 2

bullous disease without mucosal involvement

Answer 2

bullous pemphigoid

Question 3

treatment of choice for giant cell arteritis

Answer 3

high dose glucocorticoids

Question 4

treatment of giant cell arteritis in patients whom glucocorticoids alone are not effective or cannot tolerate glucocorticoids and their side effects

Answer 4

1) tocilizumab
2) methotrexate (less effective)

Question 5

treatment of choice for ankylosing spondylitis

Answer 5

NSAIDs

Question 6

treatment for ankylosing spondylitis in patients who continue to have symptoms despite NSAID use

Answer 6

1) TNF inhibitors (etanercept, adalimumab, infliximab)
2) IL-17 inhibitors (sekunimumab, etc.)
3) Janus kinase inhibitors (tofacitinib, abrocitinib, etc.)

Question 7

Drugs that are strongly associated with SJS/TEN

Answer 7

Allopurinol
Lamotrigine
Sulfamethoxazole
Carbamazepine
Phenytoin
Nevirapine
Sulfasalazine
Other sulfonamides
Oxicam NSAIDs (piroxicam, tenoxicam)
Phenobarbital
Etoricoxib
PPIs
Minocycline

Question 8

painful, dusky macules/erosions/ulcers/vesicles present on face, trunk, mucus membranes covering <10% of body surface area and sloughing

Answer 8

SJS

Question 9

painful, dusky macules/erosions/ulcers/vesicles present on face, trunk, mucus membranes covering 10-30% of body surface area and sloughing

Answer 9

SJS/TEN overlap syndrome

Question 10

painful, dusky macules/erosions/ulcers/vesicles present on face, trunk, mucus membranes covering >30% of body surface area and sloughing

Answer 10

TEN

Question 11

4 types of spondyloarthritis

Answer 11

ankylosing spondylitis
Psoriatic arthritis
Enteropathic arthritis
Reactive arthritis

Question 12

Enthesitis/dactylitis (sausage digits) indicative of what?

Answer 12

spondyloarthritis