Rheumatology Quiz Questions Flashcards
Osteoarthritis is a disorder of which structure/tissue?
Cartilage
The term for bony enlargement of the distal interphalangeal joints is:
Heberden’s nodes
All of the following are components of cartilage EXCEPT
Blood vessels
Ninety percent of the collagen in cartilage is which type?
Type II
Synovial fluid analysis in osteoarthritis reveals what type of fluid?
Type I (non-inflammatory) fluid with WBC/mm3 200-2,000
Uric acid is the end product of the metabolism of which compound:
Purines
Humans are susceptible to gout since they lack which enzyme that can oxidize uric acid to the more soluble compound allantoin:
Uricase
Which statement regarding gout is TRUE?
The majority of patients with primary gout are underexcretors of uric acid.
Regarding calcium pyrophosphate dihydrate deposition disease (CPDD), which statement is FALSE?
Like acute gout, the first MTP is commonly involved in attacks of acute pseudogout.
Hyperuricemia without symptoms is referred to as:
Asymptomatic hyperuricemia
Rheumatoid arthritis (RA) begins with inflammation in which structure/tissue?
Synovium
In RA, which small joints of the hands are spared?
DIPs
The genetic polymorphism that determines both susceptibility to and severity of RA is:
Shared epitope within the third hypervariable region of the DRB1 gene (HLA DR)
Activated macrophages in RA produce all of the following cytokines EXCEPT:
IL-17
Which statement is true regarding rheumatoid factor (RF)?
RF are immunoglobulins that recognize epitopes within the Fc portion of IgG
Myasthenia gravis, Goodpasture’s syndrome, and autoimmune thyroiditis are examples of:
Organ specific autoimmunity
Which statement regarding Systemic Lupus Erythematosus (SLE) is TRUE?
Systemic or generalized flares of disease can occur after excessive sun exposure
Which antibody may be involved in the pathogenesis of lupus nephritis?
Anti-double-stranded DNA (ds DNA) antibodies
All of the following are possible theories to explain autoimmunity EXCEPT:
Immunodeficiency due to Toll-like receptor deficiency
Strongest SLE genetic association
C4 null alleles
The primary and unique pathologic site in spondyloarthropathies is the:
Enthesis
Spondyloarthropathy genetic association:
HLA-B27
Only certain bacterial subtypes can induce reactive arthritis. These include all of the following EXCEPT:
Staph
All of the following are clinical manifestations of spondyloarthropathies EXCEPT:
Tophi
Laboratory studies characteristic of seronegative spondyloarthropathies are:
Negative rheumatoid factor (RF) and negative anti-nuclear antibodies (ANA)
The erythematous papular rash over the metacarpal or interphalangeal joints that classically occurs in dermatomyositis is known as:
Gottron’s papules
All of the following are features of the Anti-synthetase Syndrome EXCEPT:
Enthesopathies
The anti-synthetase antibody, anti-Jo-1, is directed against which aminoacyl-tRNA synthetase?
Histidyl
In polymyositis, the muscle inflammatory cell infiltrate is primarily which cell type:
CD8+ T cells
In autoimmune inflammatory myopathies, which laboratory test is elevated in the vast majority of patients with active disease:
Creatine phosphokinase (CPK)
Clinical presentations of this type of vasculitis include temporal headache, jaw claudication, scalp tenderness, and vision loss:
Giant cell arteritis
Typical histology of small vessel vasculitis:
Leukocytoclastic vasculitis
Which statement regarding Antineutrophil Cytoplasmic Antibodies (ANCAs) is TRUE?
Cytoplasmic –ANCA (c-ANCA) is common to Wegener’s granulomatosis as perinuclear-ANCA (p-ANCA) is common to microscopic polyangiitis (MPA)
All of the following are examples of immune complex (IC)-induced vasculitis EXCEPT:
Granulomatosis with polyangiitis (GPA)
All of the following are suspected immunopathogenic mechanisms that mediate vasculitis EXCEPT:
Atherosclerosis
