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Rheumatoid > Rheumatology Quiz Questions > Flashcards

Rheumatology Quiz Questions Flashcards

1
Q

Osteoarthritis is a disorder of which structure/tissue?

A

Cartilage

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2
Q

The term for bony enlargement of the distal interphalangeal joints is:

A

Heberden’s nodes

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3
Q

All of the following are components of cartilage EXCEPT

A

Blood vessels

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4
Q

Ninety percent of the collagen in cartilage is which type?

A

Type II

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5
Q

Synovial fluid analysis in osteoarthritis reveals what type of fluid?

A

Type I (non-inflammatory) fluid with WBC/mm3 200-2,000

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6
Q

Uric acid is the end product of the metabolism of which compound:

A

Purines

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7
Q

Humans are susceptible to gout since they lack which enzyme that can oxidize uric acid to the more soluble compound allantoin:

A

Uricase

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8
Q

Which statement regarding gout is TRUE?

A

The majority of patients with primary gout are underexcretors of uric acid.

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9
Q

Regarding calcium pyrophosphate dihydrate deposition disease (CPDD), which statement is FALSE?

A

Like acute gout, the first MTP is commonly involved in attacks of acute pseudogout.

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10
Q

Hyperuricemia without symptoms is referred to as:

A

Asymptomatic hyperuricemia

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11
Q

Rheumatoid arthritis (RA) begins with inflammation in which structure/tissue?

A

Synovium

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12
Q

In RA, which small joints of the hands are spared?

A

DIPs

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13
Q

The genetic polymorphism that determines both susceptibility to and severity of RA is:

A

Shared epitope within the third hypervariable region of the DRB1 gene (HLA DR)

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14
Q

Activated macrophages in RA produce all of the following cytokines EXCEPT:

A

IL-17

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15
Q

Which statement is true regarding rheumatoid factor (RF)?

A

RF are immunoglobulins that recognize epitopes within the Fc portion of IgG

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16
Q

Myasthenia gravis, Goodpasture’s syndrome, and autoimmune thyroiditis are examples of:

A

Organ specific autoimmunity

17
Q

Which statement regarding Systemic Lupus Erythematosus (SLE) is TRUE?

A

Systemic or generalized flares of disease can occur after excessive sun exposure

18
Q

Which antibody may be involved in the pathogenesis of lupus nephritis?

A

Anti-double-stranded DNA (ds DNA) antibodies

19
Q

All of the following are possible theories to explain autoimmunity EXCEPT:

A

Immunodeficiency due to Toll-like receptor deficiency

20
Q

Strongest SLE genetic association

A

C4 null alleles

21
Q

The primary and unique pathologic site in spondyloarthropathies is the:

A

Enthesis

22
Q

Spondyloarthropathy genetic association:

A

HLA-B27

23
Q

Only certain bacterial subtypes can induce reactive arthritis. These include all of the following EXCEPT:

A

Staph

24
Q

All of the following are clinical manifestations of spondyloarthropathies EXCEPT:

A

Tophi

25
Q

Laboratory studies characteristic of seronegative spondyloarthropathies are:

A

Negative rheumatoid factor (RF) and negative anti-nuclear antibodies (ANA)

26
Q

The erythematous papular rash over the metacarpal or interphalangeal joints that classically occurs in dermatomyositis is known as:

A

Gottron’s papules

27
Q

All of the following are features of the Anti-synthetase Syndrome EXCEPT:

A

Enthesopathies

28
Q

The anti-synthetase antibody, anti-Jo-1, is directed against which aminoacyl-tRNA synthetase?

A

Histidyl

29
Q

In polymyositis, the muscle inflammatory cell infiltrate is primarily which cell type:

A

CD8+ T cells

30
Q

In autoimmune inflammatory myopathies, which laboratory test is elevated in the vast majority of patients with active disease:

A

Creatine phosphokinase (CPK)

31
Q

Clinical presentations of this type of vasculitis include temporal headache, jaw claudication, scalp tenderness, and vision loss:

A

Giant cell arteritis

32
Q

Typical histology of small vessel vasculitis:

A

Leukocytoclastic vasculitis

33
Q

Which statement regarding Antineutrophil Cytoplasmic Antibodies (ANCAs) is TRUE?

A

Cytoplasmic –ANCA (c-ANCA) is common to Wegener’s granulomatosis as perinuclear-ANCA (p-ANCA) is common to microscopic polyangiitis (MPA)

34
Q

All of the following are examples of immune complex (IC)-induced vasculitis EXCEPT:

A

Granulomatosis with polyangiitis (GPA)

35
Q

All of the following are suspected immunopathogenic mechanisms that mediate vasculitis EXCEPT:

A

Atherosclerosis

Rheumatoid (1 decks)

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