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Wolfpacc Clues 2 > Rheumatology/MSK > Flashcards

Rheumatology/MSK Flashcards

1
Q

What is primary biliary cirrhosis?

A

Pruritis, xanthomas, anti-mitochondrial Ab; seen in females

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2
Q

What is primary sclerosing cholangitis?

A

P-ANCA Ab, bike duct inflammation, onion skinning, IBD

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3
Q

What is type I autoimmune hepatitis?

A

Anti-smooth mm. Ab; seen in young women

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4
Q

What is type II autoimmune hepatitis?

A

Anti-LKM Ab

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5
Q

What is bullous pemphigoid?

A

Anti-hemidesmosome Ab, subepithelial skin bullae

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6
Q

What is celiac sprue?

A

Anti-gliaden Ab (can’t eat wheat/ bread products = steatorrhea) assoc. w/ dermatitis herpetifomis

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7
Q

What Ab is assoc. w/ CREST Syndrome?

A

Anti-centromere Ab

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8
Q

What is dermatitis herpeteformis?

A

Vesicles on anterior thigh, Anti-BMZ Ab, Anti-endomysial Ab

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9
Q

What is dermatomyositis?

A

Anti-jo-1 Ab; Myositis with a rash; Assoc. w/ occult malignancy

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10
Q

What are symptoms of T1DM?

A

Polyuria, polydipsia, wt. loss, Anti-islet cell Ab, anti-GAD Ab, post-infection, DKA

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11
Q

What is drug Induced lupus(and causative drugs)?

A

Anti-histone-Ab;

Drugs:
Hydralazine 
Isoniazid 
Phenytoin
Penicillamine
Procainamide
Ethosuximide
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12
Q

What is gastritis type A?

A

Anti-parties cell, an strophic gastritis adenocarcinoma

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13
Q

What is goodpasture’s?

A

Anti-GBM Ag, attacks the lungs and kidneys, can progress to RPGN and death

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14
Q

What is Graves’ disease?

A

Anti-TSHr Ab, hyperthyroid exopthalmos, pretibial myxedema

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15
Q

What is Hashimotos?

A

Anti-microsomal Ab/anti-TPO, hypothyroid

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16
Q

What is ITP (immune thrombocytopenic purpura)?

A

Anti-platelet Ab, anti-GP IIB/IIIA Ab

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17
Q

What is MCTD (mixed connective tissue disease)?

A

Anti-RNP Ab

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18
Q

What is mononucleosis?

A

Heterophile Ab positive; teenager w/ sore throat, lymphadenopathy, splenomegaly, “kissing disease”

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19
Q

What is MPGN type II?

A

Anti-C3 convertase Ab= C3 nephritic factor

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20
Q

What is paroxysmal hemolysis?

A

Donate landsteiner Ab; bleed when cold

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21
Q

What is pemphigus vulgaris?

A

Anti-desmosome Ab (skin sloughs off when touched) starts in oral mucosa

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22
Q

What is pernicious anemia?

A

Anti-IF Ab, via. B12 deficiency = megaloblastic anemia

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23
Q

What is polyarteritis nodosa?

A

P-ANCA Ab; attacks gut, kidneys and nervous system; assoc. w/ Hep. B infection. There is no pulmonary environment

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24
Q

What is post-strep. GN?

A

ASO Ab, Nephritic w/ complement deposition; after 3 weeks post-infection

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25
Q

What is RA?

A

Rheumatoid factor present pain and swelling, worse in the morning, anti-citrullinated peptide protein Ab’s

26
Q

What is scleroderma?

A

Anti-Scl70 Ab (anti-Topol), fibrosis, tight skin, masked faces

27
Q

What is Sjogrens?

A

Anti-SSA Ab, dry eyes, dry mouth, arthritis

28
Q

What is SLE?

A

Anti-dsDNA; Anti-Smith, Anti-cardiolipin Ab.

Malar rash, photosensitivity, oral ulcers, RF positive, VDRL positive but not infected, FTA-ABS to confirm

29
Q

What is SLE Cerebritis?

A

Anti-neuronal Ab; Anti-ribosomal Ab

30
Q

What is Vitiligo?

A

Anti-melanocyte Ab; white patches on skin

31
Q

What is warm hemolysis?

A

Anti-Rh Ab; bleeds at body temperature

32
Q

What is Wegner’s?

A

c-ANCA Ab; attacks ENT, Lungs, and kidney

33
Q

What is HSP?

A

IgA Disease - 2 or 3 days post-common cold or GI infection. Leads to Berger’s

34
Q

What is Berger’s?

A

IgA disease, 2 weeks post vaccination; serum sickness

35
Q

What is Alport’s?

A

IgA disease; 2 weeks after diarrhea, HSP and polio

36
Q

Where is CK-MB found?

A

Heart

37
Q

Where is CK-MM found?

A

Muscle

38
Q

Where is CK-MB found?

A

Brain

39
Q

Why should you wait 30 mins after a meal before swimming?

A

All blood is shunted to GI for digestion, digestion depletes ATP stores; No ATP = no muscle movement

40
Q

How does neurogenic muscle disease present?

A

Distal weakness and fasciculations

41
Q

How does myopathy muscle disease present?

A

Proximal weakness and pain

42
Q

What is a light chain composed of?

A

Actin

43
Q

What is a heavy chain composed of?

A

Myosin

44
Q

What band of sarcomere does not change length?

A

The A band

45
Q

Where are T-tubules located?

A

Cardiac mm: at the z-line

Skeletal mm: at the A-I junction

46
Q

What is duchenne’s muscular dystrophy?

A

Caused by a dystrophin frame shift; defective Dystrophin patient will have a Gower sign and calf pseudohypertrophy

47
Q

What is Becker Muscular Dystrophy?

A

Dystrophin Missense; milder form of DMD

Symptoms present after 5yo

48
Q

What is seen with Myotonic Dystrophy?

A

Bird’s beak Face; can’t let go when shaking hands

49
Q

What is Myasthenic Syndrome/Lambert-Eaton?

A

Patients will tell you that they get stronger as the day goes by; stronger with EMG (electromyography)
Assoc. w/ small cell CA

50
Q

What is Myasthenia Gravis?

A

Anti-ACh post-synaptic Ab; PT ~20-30yo, weaker as day goes on (dysarthria, ptosis, dysphagia)
Periotic exacerbations get stronger w/ Edrophonium
Weaker with EMG (electromyography); must rule out thymoma

51
Q

What is MS?

A

Production of Anti-myelin Ab
MC in 20-40yo women, vision disturbances, spasticity (UMNs), decreased sensation, symptoms wax and wane - each MS attack gets worse

52
Q

What is Metachromatic Leukodystrophy?

A

Arylsulfatase A deficiency; a child who presents similar to MS

53
Q

What is ataxia telangiectasia?

A

IgA deficiency; PT has spider veins

54
Q

What do you see in Friedrick’s Ataxia?

A

Retinitis pigmentosa, scoliosis

55
Q

What is adrenal leukodystrophy?

A

Carnitine acyltransferase (CAT-1), defective adrenal failure (XR); long-chain FA stuck in cytoplasm

56
Q

What is Guillain-Barre?

A

Ab’s damage multiple peripheral nerves (acute inflammatory polyneuropathy); patients present with ascending paralysis 2 weeks post-UTI

57
Q

What is ALS?

A

Descending paralysis seen in middle aged men with fasciculations; no sensory problems

58
Q

What is Werdnig-Hoffman?

A

Fasciculations in newborn due to failure of anterior horns to develop

59
Q

What is polio?

A

Asymmetric fasciculations in kids; presents 2 weeks post- gastroenteritis

60
Q

What is choreoathetosis?

A

Dance-like movements; wringing of hands, quivering/unsteady voice

61
Q

What is Atonic Cerebral Palsy?

A

No mm. Tone - floppy

Wolfpacc Clues 2 (2 decks)

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