Rheumatology Drugs Flashcards
1
Q
methotrexate MOA
A
- MOA: interfering with the metabolism of folate and suppressing certain components of the immune system.
2
Q
methotrexate administration?
A
- Taken as an injection or tablet once a week.
3
Q
what is co-prescribed with methotrexate?
A
- Folic acid 5mg is also prescribed once a week to be taken on a different day to the methotrexate.
4
Q
SE of methotrexate?
A
- SE: mouth ulcers and mucositis, liver toxicity, PF, bone marrow suppression and leukopenia, teratogenic (avoid in both male and female).
5
Q
MOA of luflenamide
A
- MOA: interferes with the production of pyrimidine which is a component of DNA and RNA.
6
Q
SE of luflenamide
A
- SE: mouth ulcers and mucositis, peripheral neuropathy, rashes, increased BP, teratogenic.
7
Q
moa of sulfasalazine?
A
- MOA: immunosuppressive and anti-inflammatory,
- Safe in pregnancy but need adequate folic acid.
8
Q
SE of sulfasalazine
A
- SE: temporary male infertility, bone marrow suppression
9
Q
MOA of HCQ?
A
- MOA: HCQ acts as an immunosuppressant by interfering with Toll-like receptors disrupting antigen presentation and increasing pH in the lysosomes of immune cells. Safe in pregnancy.
10
Q
SE of HCQ?
A
- SE: nightmares, macular toxicity (must need a yearly retinal check), liver toxicity, skin pigmentation.
11
Q
examples of anti-TNF drugs and how they work?
A
- Tumour necrosis factor is a cytokine which is pro-inflammatory, by blocking this, it reduces inflammation.
- Examples of these include: adalimumab, infliximab, golimumab
- They are monoclonal antibodies for TNF.
12
Q
SE of anti-TNFs?
A
- SE: vulnerability to sepsis and infections.
- Reactivation of TB and hep B
13
Q
rituximab MOA
A
- MOA: monoclonal antibody which targets CD20 on B cells inducing destruction.
14
Q
SE of rituximab
A
- SE: night sweats, thrombocytopenia, peripheral neuropathy, liver and lung toxicity.
15
Q
notable SE of key rheum drugs (6) methotrexate sulfasalazine leflunomide HCQ anti-tnf rituximab
A
1) Methotrexate pulmonary fibrosis
2) Sulphasalazine male infertility
3) Leflunomide HTN and peripheral neuropathy
4) HCQ visual acuity and nightmares.
5) Anti-TNF reactivation of TB or Hep B
6) Rituximab night sweats, thrombocytopaenia.
