Rheumatology and Orthopaedics Flashcards
What are the red flags for back pain?
Age <20 or >50 history of previous malignancy night pain history of trauma systemically unwell e.g. weight loss, fever
others- thoracic pain, immunosuppression, structural deformity, neuro signs
What are back pain emergencies?
infection, malignancy, nerve compromise and fracture
What features of back pain point towards a prolapsed disc?
leg pain usually worse than back
pain often worse when sitting
What features are of a L3 nerve compression?
sensory loss over anterior thigh
weak quads
reduced knee reflex
+ve femoral stretch test
What features are of a L4 nerve compression?
sensory loss over anterior knee
weak quads
reduced knee reflex
+ve femoral stretch test
What features are of a L5 nerve compression?
sensory loss over dorsum of foot
weakness in foot and big toe dorsiflexion
reflexes intact
+ve sciatic nerve stretch test
What features are of a S1 nerve compression?
sensory loss posterolateral leg and foot
weakness in plantar flexion
reduced ankle reflex
+ve sciatic nerve stretch test
What features of back pain point towards peripheral arterial disease?
pain on walking, relieved by rest
absent or weak foot pulses
smoking history or other vascular disease
What syndromes are associated with HLA-B27?
ankylosing spondylitis
reiter’s syndrome
acute anterior uveitis
What is ankylosing spondylitis?
ankylosing= stiffness in a joint spondylitis= inflammation of the spine
What are associations of ankylosing spondylitis?
IBD
Chlamydial urethritis
psoriasis
features of ankylosing spondylitis?
lower back pain and stiffness
worse in morning and improves with exercise
reduced lateral and forward flexion
reduced chest expansion
‘A’ features of ank spond?
Apical fibrosis Anterior uveitis Aortic regurg Achilles tendonitis AV node block Amyloidosis Peripheral arthritis
Ix of ank spond?
ESR/CRP
HLA-B27
Xray of sacroiliac joints- later findings are bamboo spine, subchondrial erosions, sclerosis, squaring of the lumbar vertebrae, syndesmophytes
Tx of ank spond?
encourage regular exercise
NSAIDs
DMARDs
Anti-TNF if persistently high disease activity (must have failed 2 NSAIDs first)
What are features of spinal cord compression?
back pain- may be worse on lying down and coughing
lower limb weakness
sensory loss and numbness
nocturnal
lesions above L1-> UMN signs in legs and a sensory level
lesions below L1->LMN signs in the legs and perianal numbness
Mx if you suspect spinal cord compression?
Whole spine MRI
high dose dexamethasone
urgent oncological assessment for consideration of radiotherapy or surgery
What is cauda equina syndrome?
Damage to the cauda equina- peripheral nerves protruding from the bottom of the spinal cord
What is the structure of the spinal cord?
31 spinal nerves C8 T12 L5 S5 1 coccygeal L5 onwards travel together to form the cauda equina
What are causes of cauda equina syndrome?
lumbar disc herniation spinal stenosis AS spondylolisthesis- vertebra displaced by trauma, surgery or degeneration e.g. anterolisthesis Trauma to spine
features of cauda equina syndrome?
incontinence due to decreased tone of anal sphincter and muscles of bladder wall decreased sexual function saddle anaesthesia leg weakness sciatic pain
Diagnosis of cauda equina syndrome?
MRI/CT
Tx of cauda equina syndrome?
surgical decompression within 48 hours of sudden onset (tumour,trauma)
corticosteroids and Abx of gradual onset (degeneration)
What are general features of rheumatoid arthritis?
swollen,painful joints in hands and feet stiffness worse in mornings and hot weather gradual larger joint involvement positive squeeze test- metacarpals rheumatoid nodules
What are hand signs of rheumatoid arthritis?
swan necking Z-thumb subluxtion of the MCP muscle wasting ulnar deviation fixed flexion deformity- Boutonniere deformity
Name some eye signs of rheumatoid arthritis?
keratoconjunctivitis sicca
episcleritis/scleritis
corneal ulceration
Name some pulmonary signs of rheumatoid arthritis?
pulmonary fibrosis, pleural effusion, pulmonary modules, pleurisy, caplan’s syndrome, infection secondary to immunosuppression
Name some systemic signs of rheumatoid arthritis?
swollen bursea anaemia vasculitis lymphadenopathy splenomegaly Raynaud's Sjogren's syndrome septic arthritis amyloidosis pericarditis depression
Ix of rheumatoid arthritis?
RF circulating antibody anti-CCP antibody ESR/CRP Joint aspiration MRI XR
XR findings of rheumatoid arthritis?
Loss of joint space
Erosions (periarticular)
Soft tissue swelling
Soft bones (osteopenia)
Tx of rheumatoid arthritis?
1st line= DMARD monotherapy +/- a short course of bridging prednisolone
DMARDS- methotrexate, sulfasalazine, leflunomide, hydroxychloroquine
Can add TNF-inhibitors after 2 failed DMARDS e.g. etanercept, infliximab
Rituximab
anti-CD20 monoclonal antibody, results in B-cell depletion
two 1g intravenous infusions are given two weeks apart
infusion reactions are common
monitoring and SEs of methotrexate?
Monitor FBC and LFT due to risk of liver cirrhosis and myelosuppression
SE- pneumonitis, liver toxicity, bone marrow suppression, GI toxicity e.g. stomatitis
SEs of sulfasalazine?
Increased risk of allergy if also allergic to aspirin
SE- rashes, oligospermia, interstitial lung disease, staining of contact lenses, steven-johnson syndrome
SEs of leflunomide?
Liver impairment, hypertension, interstitial lung disease
SEs of hydroxychloroquine?
retinopathy, corneal deposits
SEs of TNF inhibitors?
reactivation of TB
What is felty’s syndrome?
RA + splenomegaly + low WCC
what causes gout?
deposition of uric acid in the synovium
causes of gout?
decreased excretion of uric acid- diuretics, aspirin, CKD, lead toxicity
increased production of uric acid- myeloproliferative disorder, cytotoxic drugs, severe psoriasis
Diet- red meat, alcohol, high sat fats
What is primary gout?
may result from an inherited gene#excess de novo purine
synthesis or reduced renal excretion of uric acid
What is secondary gout?
increased lysis of cells e.g. chemo
diuretics or chronic renal disease
features of acute gout?
70% 1st MTP- pain,swelling, erythema
features of chronic (tophaceous) gout?
occurs after many attacks asymmetrical polyarthritis cartilage and bone 'punched out' lesions deposition of urate crystals- resulting in tophi restriction of joint movements
Ix of gout?
serum urate
WCC
ESR
synovial fluid aspiration- negatively birefringent under polarised light (needle shaped)
Tx of gout?
1st line: NSAIDs and colchicine (PPI needed)
prednisolone 15mg/day in contraindicated
intra-articular steroid injection
Urate lowering therapy- allopurinol (xanthene oxidase inhibitor)
- delayed starting
-100mg OD then titrated every few weeks until serum uric acid <300umol/L
-lower initial dose if reduced eGFR
can use febuxostat instead of allopurinol
lifestyle advice- diet and alcohol
What is pseudogout?
caused by deposition of calcium pyrophosphate in the synovium
It usually presents as a monoarthritis in the elderly
knee, wrist and shoulder most commonly affected
RFs for pseudogout?
hyperparathyroidism hypothyroidism haemochromatosis acromegaly low Mg, low phosphate Wilson's disease
Ix of pseudogout?
joint aspiration- weakly positive birefringent rhomboid shaped crystals
X-ray- chondrocalcinosis
Tx of pseudogout?
aspiration of joint fluid to exclude septic arthritis
NSAIDs or intra-articular, IM or oral steroids as per gout
What is enteropathic arthropathy?
associated with IBD and coeliac disease
HLA-B27 associated
seronegative therefore ANA and ANCA negative
types of psoriatic arthritis?
Rheumatoid-like polyarthritis Asymmetrical oligoarthritis: hands and feet typically Sacroilitis DIP joint disease Arthritis mutilans
Nail changes in psoriatic arthritis?
psoriatic nail dystrophy discolouration of nails oncholysis pitting nails subungal hyerkeratosis ridging
Ix of psoriatic arthritis?
synovial biopsy- not routinely performed
XR-pencil-in-cup deformity
Tx of psoriatic arthritis?
treat as RA
DMARDS- methotrexate and leflunomide
hydroxychloroquine is avoided as it exacerbates skin disease
Causes of reactive arthritis?
follow an infection (usually an STI) where the organism can’t be recovered from a joint
STIs- chlamydia (more common in men)
Dysentry- shigella, salmonella, E.coli, campylobacter
features of reactive arthritis?
typically develops 4 weeks after infection
asymmetrical oligoarthritis, dactylitis, urethritis, eyes: conjunctivitis, anterior uveitis
skin: blennorrhagia (waxy yellow/brown apules on palms and soles), circunate balanitis (painless vesicles on prepuce), keratoderma
Ix for reactive arthritis?
bloods- ESR/CRP
stool sample
test for STIs
Tx for reactive arthritis?
symptomatic- analgesia, NSAIDs, intra-articular steroids
sulfasalazine and methotrexate are sometimes used for persistent disease
symptoms may last for up to 12 months
causes of septic arthritis?
most common organism overall is Staphylococcus aureus
in young adults who are sexually active Neisseria gonorrhoeae should also be considered
in adults, the most common location is the knee
RFs for septic arthritis?
immunocompromised DM prosthetic joint RA/OA steroids IVDU unprotected sex
features of septic arthritis?
acute onset, singular joint
gets progressively worse
concurrent infection e.g. UTI
constitutional symptoms (febrile, hypotensive, tachycardic)
Kocher criteria for the diagnosis of septic arthritis?
fever >38.5 degrees C
non-weight bearing
raised ESR
raised WCC
Mx of septic arthritis?
synovial fluid should be obtained before starting treatment
intravenous antibiotics which cover Gram-positive cocci are indicated. The BNF currently recommends flucloxacillin or clindamycin if penicillin allergic
antibiotic treatment is normally be given for several weeks (BNF states 6-12 weeks)
needle aspiration should be used to decompress the joint
arthroscopic lavage may be required
epidemiology of SLE?
black africans and indian Asians peak incidence is 25-35 years female genetic predisposition UV light exposure can be caused by chlorpromazine, hydralazine, isoniazid, procainamide
diagnostic criteria of SLE
4/11 needed for diagnosis from American College of Rheumatology-
1- Malar rash
2- Oral ulceration
3- Discoid rash (oval or round) seen in areas exposed to sunlight
4- Arthritis
5- Photosensitivity
6-Serositis
7- Neuro disorders- seizures, psychosis
8- Renal disease- proteinuria, red cell casts in urine
9- Haematological disorder- leucopenia, lymphopenia, haemolytic anaemia, thrombocytopenia
10- immunological disorder- antibodies to DsDNA, Anti-SM
11- ANA positive
Ix of SLE?
Urine dipstick- proteinuria, red cell casts
ESR is often raised but CRP is normal
ANA positive in >95%
dsDNA +ve in 65%-highly specific for SLE- used for disease monitoring
tx of acute flare ups of SLE?
IV cyclophosphamide and high-dose prednisolone
maintenance tx of SLE?
NSAIDs
Hydroxychloroquine- Useful for skin lesions, arthralgia, myalgia and malaise
Cyclophosphamide is reserved for treatment of life-threatening disease
DMARDS as steroid sparing agents
What is antiphospholipid syndrome associated with?
SLE
Features of antiphospholipid syndrome?
CLOTS Coagulation defect (thrombosis) Livedo reticularis Obstetric (recurrent miscarriage) Thrombocytopenia SLE
antibody for antiphospholipid syndrome?
anti-cardolipin
Tx for antiphospholipid syndrome?
warfarin for VTE risk
what is systemic sclerosis? (scleroderma)
vascular damage within skin and organs leads to fibrosis