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INTERNAL MEDICINE > Rheumatology and Immunology > Flashcards

Rheumatology and Immunology Flashcards

1
Q

MC type of Arthritis

A

OA - MCC of chronic knee pain in persons >45 y/o

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2
Q

pathologic sine qua non of OA

A

hyaline articular cartilage loss

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3
Q

usually SPARED joints in OA

A

AWE
ankle
wrist
elbow

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4
Q

1st line treatment in OA

A

NSAIDs and COX 2 inhibitor

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5
Q

Laboratory seen in OA and RA

A

OA: WBC <2000
RA: 5000-50,000; overwhelming neutrophil

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6
Q

Radiographic seen in OA and RA

A

OA: joint space loss or narrowing, osteophytes
RA: periarticular osteopenia (early) soft tissue swelling, joint space loss, subchondral erosion

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7
Q

This is a flexion of the PIP joint with hyperextension of the DIP joint

A

Boutonniere deformity

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8
Q

Hyperextension of the PIP joint with a flexion of DIP joint

A

Swan-neck deformity

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9
Q

Subluxation of the 1st MCP joint with hyperextension of 1st IP joint

A

Z line deformity

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10
Q

hallmark of the RA

A

Flexor tenosynovitis (trigger fingers)

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11
Q

MC pulmonary manifestation of RA

A

Pleuirits

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12
Q

MC valvular abnormality in RA

A

MR

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13
Q

Conditions with positive RF

A

SLE
Sjogren syndrome
subacute bacterial endocarditis
Hepatitis B and C

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14
Q

first choice for the early treatment of RA

A

MTX with Folic Acid
— MTX is a folate antagonist

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14
Q

DMARD given to Pregnant

A

Hydrochloroquine
Sulfasalazine

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15
Q

Conventional DMARD

A

Hydroxychloroquine
Sulfasalazine
MTX
Leflunomide

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16
Q

no adequate response to MTX

A

within 6mos, step up –> triple therapy:
MTX, Sulfasalazine, Hydroxychloroquine

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17
Q

Diuretic drugs that decrease renal excretion of the uric acid

18
Q

Clinical features seen in OA

A

Bouchard (PIP) and Heberden (DIP) Nodes

19
Q

Triad of Felty syndrome

A

nodular RA
neutropenia
Splenomegaly

20
Q

MC used HYPOURECEMIC agent

A

Allopurinol

21
Q

DIP of pencil-in-cup deformity

A

Psoriatic arthritis

22
Q

MC CHRONIC DERMATITIS in lupus

A

Discoid Lupus erythematous

23
Q

MC acute SLE rash

A

Butterfly rash

24
Q

Labtest should be monitored every 12 weeks

A

Creatinine
CBC - myelosuppresion

25
Q

Antibodies specific for SLE

A

anti- dsDNA – correlate with Disease activity: nephritis, vasculitits
anti-Smith

26
Q

Drug induced lupus

A

Lupus Makes My HIPS Extremely Painful

Methyldopa
Minocycline
Hydralazine
Isoniazid
Phenytoin
Sulfa drugs
Etanercept
Procainamide

27
Q

antibodies seen in Drug-induced lupus

A

Anti-histone

28
Q

mainstay treatment in SLE

A

Systemic Glucocorticoids

29
Q

Most serious cardiac manifestation in SLE

A

Myocarditis
Libman-Sacks endocarditis

30
Q

best screening test for SLE

A

ANA antibody

31
Q

most accurate test in Sjogren syndrom

A

Labial biopsy

32
Q

MC site of urticaria

A

extremities and face

33
Q

MC site for angioedema

A

periorbital and lips

34
Q

most potent drug for the treatment of rhinitis

A

intranasal glucocorticoid (high dose)

35
Q

DOC for the 1st prevention of ARF

A

benzathine Pen G 1.2M
Penicillin/Amoxicillin Po for 10 days

36
Q

Drugs for secondary prevention

A

Benzathine Pen G 1.2M every 4 weeks
Oral Pen V 250mg BID
Erythromycin (penicillin allergy) 25mg BID

37
Q

DUration of Prophylaxis in patient with RF without carditis

A

5 yrs last attack until 21 y/o

38
Q

Duration of Prophylaxis in patient with RF with carditis without valvular dse

A

10 yrs last attack until 21 y/o

39
Q

DUration of Prophylaxis in patient with RF with carditis and persistent valvular disease

A

10 yrs last attack until 40 y/o or sometimes lifetime

40
Q

Diagnosis of the RECURRENT ARF

A

2 major
1 major and 2 minor
3 minor

41
Q

Diagnosis of the INITAL ARF

A

2 major
1 major + 2 minor

42
Q

TOC for Anaphylaxis

A

Epinephrine 0.3-0.5mL of 1:1000 (1mg/ml) IM with repeated dose at 5-20mins interval for severe reaction

INTERNAL MEDICINE (5 decks)

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