Rheumatology

Question 1

Puffy hands, anti-U1RNP positive, dsDNA negative. Diagnosis?

Answer 1

Mixed connective tissue disease

Question 2

Antibody for limited scleroderma?

Answer 2

Anti-centromere

Question 3

Antibody for ILD in scleroderma?

Answer 3

Anti-topisomerase I aka Scl-70

Question 4

Antibody for severe renal and sin disease in scleroderma?

Answer 4

Anti-RNA polymerase

Question 5

Anti-centromere antibodies are associated with which 2 features of scleroderma?

Answer 5

Limited SSc. Pulmonary hypertension

Question 6

Antibody for pulmonary hypertension in scleroderma?

Answer 6

Anti-centromere

Question 7

Anti-topoisomerase (aka Scl-70) antibodies are associated with which 2 features of scleroderma?

Answer 7

Diffuse SSc. Interstitial lung disease

Question 8

Anti-RNA polymerase III antibodies are associated with which 2 features of scleroderma?

Answer 8

Diffuse SSc. Severe renal disease

Question 9

Which 3 antibodies (apart from antiphospholipids) are suggestive of SLE?

Answer 9

ANA, dsDNA, Anti-Smith (Sm)

Question 10

p-ANCA is associated with which antigen?

Answer 10

MPO (myeloperoxidase)

Question 11

c-ANCA is associated with which antigen?

Answer 11

PR-3 (proteinase 3) think of C3PO

Question 12

Which ANCA has a higher relapse rate?

Answer 12

c-ANCA / PR-3

Question 13

Which ANCA has a lower relapse rate?

Answer 13

p-ANCA/ MPO

Question 14

Which antibody is associated with primary Sjogren’s syndrome?

Answer 14

Anti-SSA (Ro60) - not Ro53

Question 15

Anti-SSA (Ro60) is associated with which condition?

Answer 15

Primary Sjogren’s