Rheumatology

Question 1

Differential for seronegative arthridites

Answer 1

Ankylosing spondylitis - 95% HLAB27
Reactive arthritis - 80%
Enteropathic arthritis - 75%
Psoriatic spondylitis - 50%

Question 2

Differential for deforming polyarthropathy

Answer 2

Rheumatoid arthritis
Seronegative arthopathies - particularly psoriatic
Polyarticular gout
Primary generalised OA

Question 3

Causes of vasculitis

Answer 3

Large vessel
- GCA
- Takayasu
Medium vessel
- PAN
- Kawasaki
Small vessel ANCA associated
- granulomatoisis with polyangiitis
- microscopic polyangiitis
- churg Strauss vasculitis
Small vessel other
- anti-GBM
- cryoglobulinaemic
- HSP
Other
- Bechets
- drug induced vasculitis
- vasculitis associated with CTD

Question 4

Causes of Raynaud’s

Answer 4

Primary Raynaud's 
Autoimmune
- SLE
- Sjogrens 
- Sceloroderma 
- polymyositis/dermatomyositis
- mixed connective tissue disease
Haematological
- paraneoplastic
- cryoglobulinaemia
- cold agglutinins
Drugs
- b-blockers, chemotherapy, sympanomemtic drugs
Vascular
- emboli, thoracic outlet syndrome, vasculitis
Other: carpal tunnel, emotion, vibration, frostbite