Rheumatology Flashcards
Give the classic tetrad of Henoch-Schonoein Purpura // IgA Vasculitis
Palpable purpura
Glomeruloneohritis
Arthralgia
Abdominal Pain
Give the antibody associated with drug-induced lupus, and the medications associated with it.
Antihistone Antibody
Caused by: Procainamide, Hydralazine, Chlorpromazine, and Quinidine
Minocycline
Give the antibodies associated with Lupus. Which are associated with disease activity?
ANA, nearly 100% sensitive but not specific
Anti-dsDNA, specific, correlates with disease activity
Anti-Smith, specific
Give antibodies for RA
RF, sensitive
Anti CCP, specific
Give antibodies for scleroderma (limited and diffuse)
Limited: Anti-centromere
Diffuse: Anti-Scl 70, anti-topoisomerase
Give the antibody for polymyositis/dermatomyositis
Anti-Jo-1 (anti Aminoacyl-transfer RNA synthetase)
Give autoantibody for granulomatosis with poyangiitis (Wegener)
c-ANCA and anti-proteinase 3 (PR3)
Sjogrens is associated with increased risk of…
Lymphoma, non-Hodgkin
MALT lymphoma
Type 1 RTA
SLE is associated with what chronic morbidity…
Accelerated atherosclerosis, CAD
Give the classic symptoms of reactive arthritis and associated infections
Conjunctivitis, Urethritis, and Arthritis (Also keratoderma blennorrhagicum— pustular rash in soles of feet)
GI: Salmonella, Shigella, Campylobacter, Yersinia
GU: Chlamydia and Ureaplasma
What blood pressure medications should you avoid and selectively choose for gout
Switch from thiazides to LOsartan to LOwer serum urate
Give the key skin findings, CK lab, and any key associations for Dematomyositis
Proximal muscle weakness
Gottron Papules
Héliotrope rash
Elevated CK
Strong association with underlying malignancy
Give the classic sings of antisynthetase syndrome
Subtype of dermatomyositis and polymyositis associated with poor prognosis
ILD, Raynaud phenomenon, arthritis, and anti-Jo-1
“Hair, Chair, Stair, Air (ILD), and Beer (Dysphagia)”
Give the classic findings for Granulomatosis with Polyangiitis (Wegener Granulomatosis)
Nodules of the UPPER and LOWER respiratory tract + Glomerulonephritis
+c-ANCA and anti-proteinase 3
Bx shows vasculitis and necrotizing granulomatosis
Give the classic triad for Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss)
Asthma, Eosinophilia, and p-ANCA
Describe Adult-Onset Still Disease
Daily fevers,
Salmon colored rash
Erosive arthritis
Lymphadenopathy
Splenomegaly
Seronegative
Give the two common causes of Pulmonary-Renal Syndrome and how to differentiate them
Anti-glomerular basement membrane antibody disease (GBM, or Goodpasture Syndrme)
OR
Granulomatosis with Polyangiitis (Wegener’s). Upper respiratory involvement, systemic symptoms (fever, weight loss, arthralgia, fatigue)
Give the findings and autoantibody for mixed connective tissue disease
Anti-U1-RNP (Ribonucleoprotein)
Findings of multiple rheumatic conditions
Give key findings for PMR
Women > 50
Proximal shoulder and pelvic pain WITHOUT weakness
Normal CK
Dramatic response to steroids. Look for giant cell arteritis
Define CREST Syndrome and give the autoantibody, associated problem
Calcinosis: subcutaneous calcium nodules
Raynaud phenomenon
Esophageal dysmotility
Sclerodactyly
Telangiectasia
Associated with anticentromere antibodies and pulmonary hypertension
Give clinical features, diagnosis, and treatment if Polyarteritis nodosa
Clinical Fx:
Fever, wt loss
Nodules, livedo reticularis,
Mesenteric ischemia
Myalgias, arthritis
Headache, seizures
Orchitis, MI, retinal ischemia
Dx: -ANCA, -ANA. Associated with hepatitis B and C. Micoraneurysms on arteriography. Tissue box nongranulomatous vasculitis
Txt: Prednisone and Cyclophosphamide. ACEi for htn
