rheumatology Flashcards
what antibody is positive in limited systemic scelerosis?
anti-centromere antibodies
what does CREST syndrome involve?
Calcinosis, Raynaud’s phenomenon, oEsophageal dysmotility, Sclerodactyly, Telangiectasia
what is the most common cardiac complication of marfans syndrome?
dilation of aortic sinuses
what are the antibodies elevated in Anti-phospholipid syndrome??
anticardiolipin antibodies
anti-beta2 glycoprotein I (anti-beta2GPI) antibodies
lupus anticoagulant
what are the features of Anti-phospholipid syndrome
CLOT
coagulation defect
livedo reticuaris
obstretric loss
thrombocytopenia
what are the features of behcet’s syndrome?
oral ulcers, genital ulcers and anterior uveitis
thrombophlebitis and deep vein thrombosis
arthritis
associated with HLA B51
differentiate L5 and s1 lesion
L 5 = 1 st toe sensation
S 1 = 5 th toe sensation
plant the seeds
affected
plantar flexion - S1
what are the different types of collagen?
Type I: BONE - Osteogenesis Imperfecta
Type II: carTWOlage - Chondrodysplasia
Type III: ArTHREE (Artery) - Vascular type EDS
Type IV: Under the floor (basement membrane) - Thinning and splitting of GBS causing Alport Syndrome
what conditions are assoicated with ankylosig spondylitis?
Apical fibrosis
Anterior uveitis
Aortic regurgitation
Achilles tendonitis
AV node block
Amyloidosis
how do you differentiate drug indued lupus from sle?
sparing of renal and hepatic sysfunction
features of Ankylosing spondylitis on X-ray?
sacroiliitis: subchondral erosions, sclerosis
squaring of lumbar vertebrae
‘bamboo spine’ (late & uncommon)
syndesmophytes: due to ossification of outer fibers of annulus fibrosus
which complements are low in SLE?
complement levels (C3, C4) are low during active disease (formation of complexes leads to consumption of complement)
what are syndesmophytes?
ossification of outer fibres of annulus fibrosus
