Rheumatologic Conditions

Question 1

Most common rheumatologic disease of childhood?

Answer 1

Juvenile Idiopathic arthritis (JIA)

Question 2

Which marker in JIA is associated with increased risk of uveitis?

Answer 2

ANA (antinuclear antibodies)

Question 3

When is growth typically affected in patients with juvenile idiopathic arthritis (JIA)?

Answer 3

systemic JIA, uncontrolled disease, prolonged corticosteroid use, or patients who present late to rheumatology

Question 4

What are common complications from local growth disturbances in JIA?

Answer 4

Micrognathia, leg-length inequalities, developmental hip anomalies

Question 5

MRI detects joint changes in JIA best at which joints?

Answer 5

Hip and temporal mandibular joint

Question 6

common life-threatening complication of systemic juvenile idiopathic arthritis?

Answer 6

Macrophage activation syndrome (up to 30% of children with sJIA)

Constellation of findings: persistent fever, organomegaly, cytopenia, hyperferritinemia, hypertriglyceridemia, and hypofibrinogenemia; profound depression in one or more of the blood cell lines (often initially platelets) with raised liver function enzymes and clotting abnormalities. If inadequately treated, MAS can cause multiorgan failure and death

Question 7

Subtype of JIA with the best outcome/minimal functional disability?

Answer 7

Oligoarthritis

Although chronic silent anterior uveitis develops in 20% of cases