Rheumatoid Arthritis Flashcards
What sort of Disorder
Auto immune
Is it a local reaction
No, It’s a Systemic & Progressive condition
What is the Aetiology
not fully understood, possible environmental trigger with some genetic predisposition
Uni-lateral or bi-lateral
Symmetric arthritis synovial joints, erosive, mainly joints and bone
How does Rhumatoid Arithritis start
the trigger starts to send signals out → activates T cells. Activated T cells, B cell overproduction of Ig’s produces rhumatic factor
What high level of chemical mediator is found in the joint space
High level of TNF-α, IL-1 found in joint space
What is the RA summary
- Chronic inflammation
- Damage to synovial membrane
- Destruction of cartilage, synovial membrane, erosion of bone
what is the formation of pannus
- cellular mass, rich in blood vessels inflammatory cells, which release cytokines & proteases which promote inflammation, bone resorption cellular proliferation
- as more mass is created, more blood vessels are produced → increases concentration of cytokines → degrading synovial membrane
what are the extra-artiular sites of damage
Joints are most obvious but other tissues also susceptible (However, progressively can be treated using modern treatment)
What are the main markers for RA
- Anti-citrullinated peptide antibody (ACPA)
- Rhumatoid Factor (RF)
- IL-6
- IL-17A
What is Indomethacin (INDOCID) also cused for
Also suppresses uterine contractions, & accelerates closure of ductus arteriosus in neonates
Should you take Indomethacin with food
True
Indomethacin adverse effects
Headache, vertigo, dizziness and mental confusion
Indomethacin: MOA
- Non selective COX inhibitor
- central analgesic effects
- inhibits PMN motility
Sulindac
pro-drug
