rheumatoid

Question 1

what do interleukin 1-6 do?

Answer 1

HOT TBONE stEAK
IL-1 - fever
IL-2 - T cells
IL-3 = bone marrow
IL-4 IgE
IL-5 - IgA
IL-6 - AKute phase proteins

Question 2

how many hypersensitivty reactions are there?

Answer 2

4

Question 3

what is type 1 hypersensitivity

Answer 3

immediate allergic
IgE driven –> mast cells –> histamine –> recruitment of inflammatory cells
effect: vasodilation, oedema, SM contraction, mucus productoin, inflammation
Example: anaphylaxis, asthma

Question 4

what is type 2 hypersensitivity?

Answer 4

cytotoxic antibody

mediators: IgM, IgG –> classic complement
effect: phagocytosis, cell lysis, inflammation
examples: grave disease, goodpasture, haemolytic anaemia, myosina gravis, rheumatic fever, DM

Question 5

type 3 hypersensitivity

Answer 5

immune complex mediated
medatiors: Ag:Ab complex –> complement activation –> leukocyte recruitment –> release of enzymes and other toxic molecules
neutrophils
effect: inflammation, necrotising vasculitis
example: SLE, some forms of glomerulonephritis, RA, reactive arthritis

Question 6

type 4 hypersensitivity

Answer 6

cell mediated - delayed hypersensitivty

mediators: activated T cells –> release of cytokines –> inflammation and macrophage activation, T cell mediated cytotoxity
effect: perivascular cellular infiltrates, oedema, cell destruction, granuloma formation
example: TB, IBD, MS, mantoux, contact dermatitis