Rheumatic fever Flashcards
what type of immunity reaction?
immune mediated delayed response to grp A strep
cross reacts with
cardiac myosin and sarcolemma memb.
Hla?
HLA DR 3
B cell alloantigen
what kind of degenration?
fibrinoid
what phases of Rf have ascoff nodules?
subacute or chronic phases
caterpillar cells??
RF
mc callum patches
LA
fish mouth or button hole valves
RF
diagnosis
modified T. Ducket-Jones criteria
murmer
soft systolic due to MR
a soft mid diastolic murmer- carey coomb murmer due to valvulitis
mc major maifestation and occuring early when strept antibody high
Arthritis
Acute painful asymmetric migratory
erythema marginatum
occurs mainly on trunk and proximal extremities
NOT on face
subcutaneous nodules
painless
over extensor surface of bones pr tendons