Rheumatic Fever Flashcards
Define rheumatic fever and rheumatic heart disease
An inflammatory multisystem disorder that arises as a delayed complication of infection of the upper respiratory tract (pharyngeal/SORE THROAT) with beta haemolytic streptococci
Chronic rheumatic heart disease = scarring and chronic inflammation of the heart and valves → heart failure, murmurs, and damage to the valves
Aetiology of rheumatic fever
Type 2 hypersensitivity
Pharyngeal infection with Lancefield group A beta-haemolytic streptococci triggers rheumatic fever 2-4weeks later.
An antibody to the cell wall of the streptococcus cross-reacts with valve tissue (antigenic mimicry) and may cause permanent damage to the heart valves
Tends to recur unless prevented.
Risk factors for rheumatic fever
Age (4-9yrs)
Sex - Females preponderance in mitral stenosis
Severity of the infection and magnitude of immune response
poverty
overcrowded living quarters
family history of rheumatic fever (specific HLA class II alleles associated with disease)
D8/17 B cell antigen positivity
Symptoms of rheumatic fever
2-5 weeks after a Group A beta-haemolytic streptococci infection
Malaise
Fever, malaise, anorexia
Joint pain and swelling: large joint polyarthritis
Reduced movement
Breathlessness, chest pain, palpitations (carditis)
Rash
Criteria for rheumatic fever
Jones criteria: 2 major OR 1 major + 2 minor
Major:
- Carditis (tachycardia, aortic/mitral regurgitations, Carey Coombs murmur, pericardial rub, CCF, cardiomegaly, conduction, apical systolic murmur)
- Arthritis (flitting polyarthritis, usually in larger joints)
- Subcutaneous nodules (small, mobile, painless nodules on the joints and spine)
- Erythema marginatum (Geographical-type rash with red, raised edges and clear centre, mainly found on the trunk, thighs and arms)
- Sydenham’s chorea (involuntary semi-purposeful movements). May be preceded be emotional lability and uncharacteristic behaviour or slurred speech
Minor:
- Fever
- Raised ESR or CRP
- Arthralgia
- Prolonged PR interval and QT interval
- Previous rheumatic fever
Investigations for rheumatic fever
Throat swab/culture: growth of beta-haemolytic group A strep
Rapid antigen testing: +ve for group A strep
ECG: prolonged PR/QT, evidence of pericarditis
ESR/CRP: raised
FBC: raised WCC
Blood cultures
ASO titre: raised/rising
CXR: chamber enlargement, CHF
Echo: valve disease, regurgitation, pericardial effusion, chordal thickening
Histology: Aschoft + antischkov myocytes
Management for rheumatic fever
- Admit
- A-E assessment
- Supportive:
- Bed rest until CRP is normal for 2 weeks
- Start with paracetamol until diagnosis is confirmed → High-dose Aspirin (suppresses the inflammatory response of the joints and heart) or NSAIDs - Abx e.g. benzathine benzylpenicillin single dose IM
- amoxicillin (alternative); azithromycin (pen-allergic) - Consider other presentations
- CCF, cardiomegaly, 3rd degree heart block → corticosteroids
- If the fever and inflammation does NOT resolve rapidly → Corticosteroids
- Sydenham’s chorea → haloperidol, diazepam - Prophylaxis → monthly injections of benzathine penicillin (every 4 weeks)
- Until 10 years after the last episode OR until the age of 21 years (OR lifelong if severe valve disease)
- Surgical treatment with valve repair or replacement may be required
Complications of rheumatic fever
Valve disease (60-80% acute to chronic)
- Mitral (70%)
- Aortic (40%)
- Tricuspid (10%)
- Pulmonary (2%)
Rheumatic heart disease (30-50%)
Prognosis for rheumatic fever
- Without treatment, symptoms resolve within several weeks BUT can progress to rheumatic heart disease
- Symptoms resolve within several weeks with treatment
- Cardiac inflammation will lasts weeks-months
- Patients with ARF should expect to make a complete recovery from the arthritis, fever, and chorea
- Risk of repeated episodes