Rheum final review pt2 Flashcards

1
Q

In advanced RA undergoing surgery, what are you concerned about? What must you do?

A

there is synovial tissue btwn odontoid process of C2 and C1 keeping it in place.
This lining can be eroded in RA patients.
This is an issue if they have to go under general anesthesia and get neck hyper-extended to be ET tubed, you need to do flexion-extension view of the neck to see if there is an odontoid atlanto-axial subluxation. If you don’t, the odontoid peg could hit the spinal cord and could cause paralysis.

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2
Q

Dx of Fibromyalgia syndrome

A

chronic pain above and below the waist in 3 diff quadrants for 3 months or more (that doesn’t have another explanation)

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3
Q

Associated symptoms besides the diagnostic criteria for Fibromyalgia (9)

A
Irritable bowel
Irritable bladder
Chronic fatigue
Restless legs
Postural hypotension
Dizziness
“Fibro-fog”
Cold intolerance
Multiple sensitivities
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4
Q
What are these sx associated with?
Irritable bowel
Irritable bladder
Chronic fatigue
Restless legs
Postural hypotension
Dizziness
“Fibro-fog”
Cold intolerance
Multiple sensitivities
A

Fibromyalgia

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5
Q

What are the 3 FDA approved tx for Fibromyalgia?

A

Pregabalin (Lyrica),
Duloxetine (Cymbalta - MC one used),
Minacipran

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6
Q

What are 3 non-approved but freq used drugs to tx Fibromyalgia?

A

Tricyclics
Short acting hypnotics
Muscle relaxants (Cyclobenzprine)

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7
Q

Non-medication therapies indicated for Fibromyalgia (4)

A

Patient education
Encourage gradual exercise
Assess their sleep
Treat psych distress

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8
Q
Still's disease. (sx onset of JRA)
Characterized by (2)
Other sx (4)
A

High fevers & transient rash

Lymphadenopathy, hepatosplenomegaly, pleural effusions, huge leukocytosis

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9
Q

Still’s Disease is the systemic onset of ____

A

Juvenile Rheumatoid Arthritis

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10
Q

> 50 yo patient has stiffness & pain in shoulder girdle. What is this?
What test level would you notice?

A

PMR

ESR elevated, systemic

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11
Q

What is the key 95% finding in PMR?

when is the pain worse in PMR?

A

Symmetric shoulder girdle pain

Morning&raquo_space; Evening

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12
Q

List the systemic sx of PMR (9)

A
symmetric shoulder pain
pelvic pain
upper arm pain
thigh pain
Weight loss
Fever
Malaise
Difficulty standing
Difficulty grooming
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13
Q

Findings in Temporal Arteritis
which gender? average age?
Sx?

A

usu women, mean age is 74

Pain in jaw, new headache late in life, unequal blood pressure in extremities, bruits.

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14
Q

Gold standard to dx temporal arteritis

Tx of temporal arteritis

A

Temporal artery biopsy

Tx: prednisone and aspirin for 4 weeks

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15
Q

Cluster of sx found in Lupus: (2 clusters)

A

Cutaneous, articular and renal manifestations tend to appear “together”
CNS thrombotic and muscular symptoms also cluster, although to a lesser extent

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16
Q

What does the body produce in Sjogren’s syndrome?

A

Anti-SSA and/or Anti-SSB

17
Q

___ is specific for Lupus

Also, must check the UA looking for __

A

Anti-Sm (Smith)

protein

18
Q

What will a CBC look like w/ Lupus?

A

penias: anemia with - thrombocytopenia, lymphopenia, & neutropenia

19
Q

In Idiopathic inflammatory myositis
(Muscle weakness with inflammation in the muscle tissue)
What are the enzymes associated? Which are muscle/liver/both-related?

A

Elevation of serum muscle enzymes:
Muscle only: CPK, Aldolase
Liver only: ALT
Muscle & Liver: AST, LDH

20
Q

SLE has a ___ staining pattern

Drug-induced a ____ staining pattern.

A

speckled ANA

homogenous ANA

21
Q

Risk factors for developing OA (6)

A

Age
Sex - W: Knee & hand; M: hip
Genetic predisposition
Obesity (b/c of adipokines)
Malalignment (ex: scoliosis, valgus/varus deformity at knee)
Congenital condition (ex: Legg-Calve-Pethes - osteo necrosis of epiphysis)

22
Q

Arthritis along with Malar rash, photosensitivity, nephropathy, oral ulcers (but mainly the malar rash) are common signs of:

A

SLE

23
Q

What is this?

joint swelling, stiffness, increasing pain as the day goes on

A

OA

b/c as you bear weight across this joint, the most weight & pressure on irregular cartilage.

24
Q

OA:

Synovial fluid looks

A

Yellow, clear, WBC <2000, no crystals

25
Q

4 common locations of OA: (which is most common?)

Phys findings

A

Hand-70% - most common site of OA. Base of thumb
Spine-60%
Knee-30%
Hip-10%
Must involve some DIP joints, and few MCP joints