Rheum/Derm 2

Question 1

What are the lab values that distinguish between the various types of osteitis fibrosis cystica?

Answer 1

Both have high PTH but one is a primary overproduction and the other is due to non-responsiveness of the renal tubules to PTH resulting in high PTH and paradoxical Ca and Phosphate values

Question 2

What are the two most important potential complications of Paget’s disease of bone?

Answer 2

1) High output heart failure due to increased shunts

2) Osteosarcoma

Question 3

Which bone disease is caused by a deficiency of Carbonic Anhydrase II?

Answer 3

Osteopetrosis - Osteoclasts become unable to create acidic environment necessary for bone resorption