Rheum Antibodies, genetics, and other stuff

Question 1

HLA-B27

Answer 1

PAIR: Psoriatic arthritis, ankylosing spondylitis, IBD, reiter syndrome

Question 2

HLA-DR2

Answer 2

SLE

Question 3

HLA-DR3

Answer 3

SLE, Sjogrens

Question 4

HLA-DR4

Answer 4

RA, MCTD

Question 5

C-ANCA

Answer 5

Wegener’s granulomatosis

Question 6

P-ANCA

Answer 6

Churg-Strauss, microscopic polyangiitis (polyarteritis nodosa?)

Question 7

Anti-basement membrane

Answer 7

Goodpastures

Question 8

Anti-CCP

Answer 8

RA

Question 9

Anti-centromere

Answer 9

CREST

Question 10

Anti-desmosome

Answer 10

Pemphigus vulgaris

Question 11

Anti-dsDNA

Answer 11

SLE

Question 12

Anti-endomysial

Answer 12

Celiac Sprue

Question 13

Anti-Fc IgG (RF)

Answer 13

SLE, RA, many others

Question 14

Anti-gliadin

Answer 14

Celiacs

Question 15

Anti-hemidesmosome

Answer 15

Bullous pemphigoid

Question 16

Anti-histone

Answer 16

Drug-induced lupus

Question 17

Anti-Jo-1

Answer 17

Polymyositis/dermatomyositis

Question 18

Anti-microsomal

Answer 18

Hashimotos

Question 19

Antimitochondrial

Answer 19

PBC

Question 20

ANti-nAChR

Answer 20

Myasthenia gravis

Question 21

ANA

Answer 21

SLE, RA, many others

Question 22

Anti-peroxidase

Answer 22

Hashimotos

Question 23

Anti-Scl070 (anti-topoisomerase)

Answer 23

Diffuse scleroderma

Question 24

Anti-Sm (smith?)

Answer 24

SLE

Question 25

Anti-smooth muscle

Answer 25

Autoimmune hepatitis

Question 26

Anti-SSA/SSB (anti-Ro/La)

Answer 26

Sjogrens

Question 27

Anti-thyroglobulin

Answer 27

Hashimotos

Question 28

Anti-TSH (TSI)

Answer 28

Graves

Question 29

Anti-U1-RNP

Answer 29

MCTD

Question 30

Anti-VGCC

Answer 30

Lambert-Eaton myasthenic syndrome