Rheum antibodies Flashcards

1
Q

Anti nuclear factor

A

SLE (80-90%)
Systemic sclerosis
Sjogrens

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2
Q

Anti single strand DNA

A

SLE

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3
Q

Anti double strand DNA (anti-dsDNA)

A

SLE - correlates with disease activity

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4
Q

Anti-histone antibodies

A

SLE and drug induced LE

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5
Q

Anti-Sm (smith)

A

SLE

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6
Q

Anti-RNP

A

Mixed connective tissue disease
SLE (not sensitive)

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7
Q

Anti-Ro

A

Sjogren’s syndrome and SLE

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8
Q

Anti-La

A

Sjogren’s syndrome and SLE

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9
Q

Anti-centromere

A

Scleroderma
Systemic sclerosis

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10
Q

Anti- nucleolar RNA

A

Systemic sclerosis

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11
Q

Anti-Scl 70

A

Diffuse cutaenous systemic sclerosis

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12
Q

Anti-PM/Scl

A

Polymyositis and systemic sclerosis overlap syndrome

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13
Q

Anti Jo 1

A

Dermatomyositis

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14
Q

Anti-ribosomal P

A

SLE

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15
Q

Rheumatoid factor

A

Rheumatoid arthritis
Sjogrens
Normal people

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16
Q

Anti CCP

A

Rheumatoid arthritis

17
Q

Antiphospholipid antibodies

A

Anti cardiolipin is a the most commmonly detected antiphospholipid Ab
Primary antiphospholipid syndrome
SLE

18
Q

ANCA - anti neutrophil cytomplasmic antibodies

A

Granulomatosis with polyangitis GPA (Wegners)
Microscopic polyangiitis (MPA)
Eosionphillic granulomatosis with polyangiitis (EGPA/ Churg Strauss syndrome)

19
Q

cANCA

A

Granulomatosis with polyangitis GPA (Wegners)

20
Q

pANCA

A

Eosionphillic granulomatosis with polyangiitis (EGPA/ Churg Strauss syndrome)

21
Q

AMA antimitochondrial

A

PBC Primary Biliary Cirrhosis