Rheum antibodies

Question 1

Anti nuclear factor

Answer 1

SLE (80-90%)
Systemic sclerosis
Sjogrens

Question 2

Anti single strand DNA

Answer 2

SLE

Question 3

Anti double strand DNA (anti-dsDNA)

Answer 3

SLE - correlates with disease activity

Question 4

Anti-histone antibodies

Answer 4

SLE and drug induced LE

Question 5

Anti-Sm (smith)

Answer 5

SLE

Question 6

Anti-RNP

Answer 6

Mixed connective tissue disease
SLE (not sensitive)

Question 7

Anti-Ro

Answer 7

Sjogren’s syndrome and SLE

Question 8

Anti-La

Answer 8

Sjogren’s syndrome and SLE

Question 9

Anti-centromere

Answer 9

Scleroderma
Systemic sclerosis

Question 10

Anti- nucleolar RNA

Answer 10

Systemic sclerosis

Question 11

Anti-Scl 70

Answer 11

Diffuse cutaenous systemic sclerosis

Question 12

Anti-PM/Scl

Answer 12

Polymyositis and systemic sclerosis overlap syndrome

Question 13

Anti Jo 1

Answer 13

Dermatomyositis

Question 14

Anti-ribosomal P

Answer 14

SLE

Question 15

Rheumatoid factor

Answer 15

Rheumatoid arthritis
Sjogrens
Normal people

Question 16

Anti CCP

Answer 16

Rheumatoid arthritis

Question 17

Antiphospholipid antibodies

Answer 17

Anti cardiolipin is a the most commmonly detected antiphospholipid Ab
Primary antiphospholipid syndrome
SLE

Question 18

ANCA - anti neutrophil cytomplasmic antibodies

Answer 18

Granulomatosis with polyangitis GPA (Wegners)
Microscopic polyangiitis (MPA)
Eosionphillic granulomatosis with polyangiitis (EGPA/ Churg Strauss syndrome)

Question 19

cANCA

Answer 19

Granulomatosis with polyangitis GPA (Wegners)

Question 20

pANCA

Answer 20

Eosionphillic granulomatosis with polyangiitis (EGPA/ Churg Strauss syndrome)

Question 21

AMA antimitochondrial

Answer 21

PBC Primary Biliary Cirrhosis