Rhabdomyosarcoma Flashcards
1
Q
Cells of Origin
A
Mesenchymal stem cells
- These are multipotent stromal cells that can differentiate into variety of cell types like osteoblasts, chondrocytes, myocytes and adipocytes.
2
Q
Can be associated with
A
NF-1
Li-Fraumeni
3
Q
What type of sarcoma is this
A
Sarcoma + LN involvement
4
Q
List the Sarcomas + LN Involvement
A
CARE
C: Clear cell
A: Angiosarcoma
R: Rhabdomyosarcoma
E: Epithelioid
5
Q
H & P
A
if needed examination under anesthesia
Scrotal US if paratesticular
LP if parameningeal
Cystoscopy if GU involvement
6
Q
Labs
A
CBC, CMP, LDH, LFTs, UA
7
Q
Imaging
A
MRI of primary site with contrast
CT CAP
PET-CT
MRI Spine if Para meningeal involvement
8
Q
Where would you get biopsy from
A
Primary site core biopsy or incisional biopsy
9
Q
When would you do a Bone marrow biopsy
A
If
- Unfavorable histology
- T2
- LN +ve
- Chest mets
