Revision Med Year 1 Flashcards
Tetrahedral hybridisation
Sp3
Planar hybridisation
Sp2
Linear hybridisation
Sp
Hydrogen hybridisation and shape
s & sphere
What is the hybridisation of benzene
sp2
How many sigma and pi bonds are in a double bond
1 sigma
1 pi
How many sigma and pi bonds are in a triple bond
1 sigma and 2 pi
Which orbital overlap create a pi bond
P orbitals
Write down the confirmations of butane from most to least stable
Anti-staggered
Gauche staggered
Eclipse
Syn eclipsed
What does E and Z mean
E - enemies so opp sides
Z- ze same side
Equation for calculating specific optical rotation
[a] = a/cl
concentration = g/ml Length = dm
1dm = 10cm
How to calculate number of stereoisomers?
2 to the power of number of chiral centres
What is a meso compound?
A compound which contains a chiral centre but is superimposible on its own image
What is the level of sodium in the body?
4 moles
What is the level of sodium in serum
140mM
What is the level of potassium in the cells?
150mM
What is the serum level of potassium?
4-5mM
What is lithium carbonate used for as a drug?
Treats bipolar disorder and depression because reduces suicidal risk
Which drugs can chelate calcium
Tetracyclines and quinolones
What is the role of calcium as a drug?
Used to treat hypertension and angina
What is magnesium carbonate used for as a drug
Indigestion
Where is strontium used in?
In sensitivity toothpaste we have strontium chloride
Which element is found in vitamin B12?
Cobalt
Which enzyme is zinc found in?
ACE - angiotensin concerting enzyme
Normal level of iron for women in the body?
115-165 g/L
Normal level of iron in men?
130 - 180g/L
What is the ionic radius of sodium
1.02 Armstrong
What can a deficiency of potassium lead to?
Muscle weakness
How much magnesium is in the cells?
10mM
Why is barium Sulfate used in X-rays
Opaque
Doesn’t dissolve so won’t affect water potential
Use of platinum as a precious metal
Cisplatin - cancer drug
Use of silver in medicine
Silver salt is used to treat warts
Use of gold in medicine
Used to treat rheumatoid arthritis - sodium autothionalate
Which phosphorus isotopes are B emitters?
P32 and P33
Which sulfur isotope is a B emitter?
S35
Use of sulfur in oxidation state of 0
Insulin
Use of sulfur with oxidation state +2
Omeprazole
Use of sulfur with oxidation state of -2
Thiols- ace inhibitors which block zinc
Use of sulfur with oxidation state +4
Sulphanilamide drugs as an antibiotic
Use of sulfur with oxidation state +6
SLS
What is scandium in drugs used to treat
Amoebic dysentery
Which fruit is high in pottasium and how much is found in it?
Bananas
400mg
Which veg has low pottasium
Carrots
Can drugs increase levels of sodium
Yes penicillin can
Molarity definition
Moles of solute / volume of solution (L)
Units - M
Definition of molality
Moles of solute / weight of solvent (kg)
Units: molkg-1
Definition if w/v%
(g / ml) x 100
Moles fraction
Moles of desired / total moles
Definition of equivalents
Ionic valency x moles
Give examples of 4 sp3 hybridised compounds
Water
Ester
Amine
Alcohol
Why is SYN eclipsed less stable than eclipsed?
This is because if pitzer strain which is repulsion between the negative electrons in the eclipsing bond
Steric strain which is repulsion between groups in close proximity
Why is axial conformation less stable than equatorial
This is because of 1,3 diaxial interactions