REVIEW QUESTIONS Flashcards
Bleeding Time is used to evaluate the activity of:
Platelets
Which of the following test results is normal in a patient with classic von Willebrand’s disease?
Platelet count
No bleeding is observed in deficiency of which of the following factors?
XII
Hemolytic Uremic syndrome is associated with:
E.coli
Coagulation Factors affected by Coumarin Drugs:
II, VII, IX, X
Thrombotic thrombocytopenic purpura is characterized by:
Increase platelet aggregation
A protein that plays a vital role in both coagulation and platelet aggregation:
I
The defect characterizing Gray’s Syndrome:
Alpha Granule
Factor XIII is activated by which factor?
IIa
Factor V is a cofactor to factor X to activate factor II
True
What clotting factors are inhibited by Protein S
V and VIII
What is the second phase of secondary hemostasis?
Activation of Factor X
Several hours after birth, a baby boy develops petechiae and a hemorrhagic diathesis. Platelet count is 8,000/uL. What is likely the explanation?
Isoimmune Neonatal Thrombocytopenia
When performing platelet aggregation studies, which is most likely associated with Bernard Soulier Syndrome?
Normal to Epinephrine, Decreased to Ristocetin
Which of the following is a characteristics of acute idiopathic thrombocytopenic purpura?
Spontaneous remission within a few weeks
Factor XIII is a serine protease
False
Which of the following inhibitors inhibit Factor IIa?
Both; Protein C and Antithrombin III
Which of the following is correct regarding acquired thrombotic thrombocytopenic purpura?
Autoimmune Disease
TAFI target protein:
Fibrin
Which step requires calcium?
Factor XIII activation
Giant platelet is associated with which condition:
Bernard Soulier Syndrome
Platelet abnormality will affect both bleeding time and clotting time
True
Which of the following is associated with post transfusion purpura?
Immune mediated thrombocytopenia/Alloantibodies
Thiazide diuretics results to:
Decreased Platelet Production
Which of the following Factors is used only in the Extrinsic Coagulation Pathway?
VII
Hereditary hemorrhagic telangectasia is a disorder of
Connective Tissue
Which of the following coagulation factors is considered to be labile?
V
What role does vitamin K play in the Prothrombin group?
Carboxylates the factors to allow calcium binding
Factor I deficiency will affect APTT and PT
True
Aspirin prevents platelet aggregation by inhibiting the action of which enzyme?
Cyclooxygenase
Which statement regarding protein C is correct?
Activity is enhanced by Protein S
Thrombocytopenia may be associated with
Hypersplenism
The APTT is sensitive to a deficiency of which clotting factor?
None
Which of the following factors will activate factor XI?
Hageman Factor
Lumi-aggregation measures:
Aggregation and ATP release
APTT is used to?
Both; Monitor heparin therapy and evaluate the common pathway
Neurologic findings may be commonly associated with which of the following disorders?
TTP
True of TTP and DIC:
APTT prolonged in DIC
Which of the following tests is most likely to be abnormal in patients taking Aspirin?
Bleeding Time
Platelet aggregation response for Glannzmann’s Thrombasthenia
Normal to Ristocetin, Decreased to Epinephrine
Thrombin-Trombomodulin complex is necessary for the activation of:
Protein C
Scott syndrome will affect which of the following?
Secondary Hemostasis
