Review Deck Flashcards
better for pregnancy drugs?
Labatalol, methyldopa, nifedipine
Cause Angioedema 10 times more frequently in African American’s
ACE-I’s.
which thiazides like diuretics and CCB’s for hypertension (CHLORATHIAZONE?)
African american’s
Diabetes with PROTEINuria - than you need to be on an
ACE-I
which drugs protect the kidney via the RAAS system for AA’s w/ microalbuminuria?
ACEI’s and ARBs
when Renin goes up it increases BP. In our blood pressure management we have water retention and increased salt so we try to stop this process
RAAS System - juxtaglomeruluar cells cause renin release, maculodensal cells monitor sodium and cause salt and water retention
Water pills (like hydrochlorthiazide) cause hyponatremia and hypokalemia and ** hypercalcemia - makes you thrombogenic and more likely to form a clot - why does this matter with thiazides?
if I have high cholesterol the water pill is going to INCREASE my lipids and the potential that I form a dangerous clot
Cliff Claven:
MI - subendocardial ischemia (inside of heart damaged as opposed to transmural death) Non- STEMI=subendocardial ischemia which is only part of the heart and STEMI is transural
Not yet
Angina - constriction of the heart or CHEST DISCOMFORT - Stable vs unstable?
PM angina?
unstable is either first time with chest pain, chest pain different than baseline, or past chest pain that doesn’t go away at rest… unstable we treat like STEMI…
Stable angina is no change in baseline…
Printz Metal Angina is like a spasm that happens in the PM between 0000 and 0500 ish and they have normal vessels when they go to the catch lab… associated with Reynauds and treated with a CCB.. unlike STABLE OR UNSTABLE Angina where CCB is the last resort for treatment because they effect the pump (preload and afterload also) lots of side effects
Heart failure - the pump is either not contracting appropriately (preserved ejection fraction AKA diastolic)… or reduced ejection fraction (Systolic) which implies the heart doesn’t have enough pump (MI or disease). ____ (this drug) KEY IN BOTH (BUT more in preserved to keep potassium in the heart)
SPIRONOLACTone
what are our goals in diastolic vs systolic ADHF?
For systolic our goal is to improve contractility, for diastolic our goal is to spare amount of blood heading to the right of the heart
45 y/o male with rapid relief of chest pain - stable angina - __ ___ ___ - provides rapid relief in recurrent angina attacks - faster than IV or nitro patch -
nitro SUBLINGUAL tablet
STAY AWAY FROM CLASS B AND CLASS C IN LIFE AND ON THE TEST… EXTENSIVE SIDE EFFECT PROFILES!!!!
47 y/o male intentional digoxin overdose - Pulse 50 bpm - 3rd degree heart block - serum potassium is normal - SE’s: yellowish vision, causes heart blocks, etc. (on most exams if a drug in a list caused a heart block it’s usually digoxin) In addition to antiarrythic agents which is the most appropriate treatment?
Digoxin Immune FAB (digibind) IV (MUST BE IV)
5 y/o history of dry cough - which drug were they treated with to cause it?
Choices:
Losartan, remopril, Digoxin (non specific), Verapamil (CCB non DHP), Bisoprolol? (Beta blocker) -
Obviously we would chose Remopril because it’s the only ACEI
PT is on the following: Hydrochlorizide (water pill) terazosin (alpha blocker) aspirin, Diltiazem (CCB non DHP), losartan (ARB), also suffering from bradycardia - THE DRUG MOST LIKELY TO CAUSE BRADYCARDIA?
CCB most likely to cause bradycardia so Diltiazem - REMEMBER THAT CCB’s work at the AV NODE - IF IT EFFECTS AV OR SA NODE WRITE IT OUT***WHICH ONES WHERE BECAUSE THAT IS A LOT OF THE EXAM!!!
THERE WILL BE TEST QUESTIONS ON WHICH ONES EFFECT SA vs AV node
take a look and add a CARD HERE**
Creatine elevated and proteinuria which drug MUST you be on?
ace-I followed by an ARB are DOCs
Cliff craven: this means we are in kidney damage or failure - proteinuria is earliest sign of kidney failure - how do we preserve kidney function?
what ‘s the only reason a BUN is low?
BUN is elevated?
Creatinine is HIGH?
what ‘s the only reason a BUN is low? LIVER FAILURE**
BUN is elevated? Liver damage
Creatinine is HIGH*** Kidney failure
—-if you do a Chem 7 it shows up with CREATINE and BUN - males should have higher creatinine
69 y/o AA in stage 3 with NYHC level 3 (issues at rest) reduced ejection fraction failure - 39%, currently taking ACE-I with BB, with daily dose of loop diuretic - ejection fraction continues to drop - which of the following would you add to decrease morbidity?
ANSWER = combination of two drugs to treat BIDIL = hydralizine +isosorbide dinitrate… any patient with ACE-I and BB with reduced ejection fraction need to add something else to get this goal.. if you’re adding something else it is most likely BIDIL and in this case hydralizine + isosorbide dintrate (BIDIL)
—— other options were adding stuff that he’s already on
Lupus SE’s?
Procainimide (has a lupus like SE’s… so does Hydralazine)
32 y/o F with diabetes, comes in for blood pressure and pregnancy check - what do you treat her routine hypertension… which drug will you use to treat her routine HTN?
methyldopa for ROUTINE…. if it was URGENT what would we use? Labetolol… later flash card explains why
NEVER use Lisinopril, Losartan, Beta blockers (other than Labatalol) OR Hydrochlorthiazide in these patients:
in a pregnant patient - will kill the baby!!!
No Lisinopril, Losartan, BB’s other than Labateolol, or Hydrochlorothiazide
Don’t use BB’s in pregnancy (other than )
labateolol
62 y/o patient in heart failure - Px meds with benefit for cardiac remodeling and mortality - class of drug recommended first line?
ACE-I is always first
retinopathy… patient has papilledema and blurry vision?
HTN EMERGENCY
Secondary HTN: one cause that you can’t use ACE-I….
renal artery stenosis!
Concomitant Diseases:
Each with at least one question this exam
– Diabetes Mellitus with Albumineria – Secondary Stroke Prevention – Chronic Kidney Disease (CKD) – Stable Ischemic Heart Disease (SIHD) – Heart Failure
• In adults with Diabetes Mellitus (DM) and hypertension
– Antihypertensive drug treatment should be initiated at a BP of 130/80 mm Hg or higher with a treatment goal of ?
– All first-line classes of antihypertensive agents (i.e., diuretics, ACE inhibitors, ARBs, and CCBs) are useful and effective
– ACE inhibitors or ARBs may be considered in the presence of?
< 130/80 mm Hg
albuminuria
• Remember that Beta Blockers can mask DM, worsen Asthma, and disturb lipid metabolism
____ is also indicated for secondary stroke prevention, alone or in combination with aspirin,
though combination therapy may not be more effective and increases the risk of bleeding. _____ is also used to prevent thrombosis in patients with intermittent claudication, chronic arterial occlusion, atrioventricular shunts or fistulas, open heart surgery, and sickle cell anemia.
Clopidogrel
Straining to urinate - enlarged prostate with High blood pressure - any of the zosins will work, but (____ is MOST EFFECTIVE to treat both) -
____ has othrostatic hypotension on FIRST DOSE - all people who have alpha blocker you must give the 1st dose in the clinic
Doxazosin most effective for both
terazosin has orthostatic hypotension
Hypertensive emergency with hx of ischemic heart disease, kidney, and liver disease - treat with what and why?
NITROGLYCERIN due to short half life and you can titration to effect (not metabolized in the liver)
Only time you use esmolol -
aortic dissection - high doses arterial dialation low dose is veinous dialation - ripping and tearing in chest think ESMOLOL
What BB’s are recommended for HF with a reduced ejection fraction - #1 BB’s, ACEI’s, Aldosterone antagonist (spiro), and loop diuretic for symptoms
Hint this BB has alpha and beta blocker -
carvedilol - #1 drug used to treat heart failure ADHF
when you’re old you don’t want alpha response, but you do when you’re young (you want metoprolol because it’s beta selective)
what is NITROPRUSSIDE CI’d in?
It’s metabolized in the liver (cyanide) and if there is a liver disease you cannot take NITROPRUSSIDE
when you’re old you don’t want ___ response, but you do when you’re young
you want metoprolol because it’s beta selective in olds
Patients over 60 with ischemic heart disease or heart failure should still be prescribed beta-blockers for heart failure and angina. … ____ is a good choice, as it is inexpensive and proven to reduce mortality in patients with a history of MI or heart failure.
Metoprolol
61 y/o M with reduced ejection fraction - stage 3 - chronic stable angina - currently on lisinopril (ACE-I), also on BIDIL (hydralizine, nitro) and he’s also on NITRO by itself, which drug is he missing?
He needs to be on a BETA BLOCKER = carvedilol
47 yo/ M with Stage I hypterenstion, which med do we start -
ALWAYS start with hydrochlorthiazide or chlorithalidone and build from there (HMMMM WHAT ABOUT AN ACE-I?)
Which vasodialator is a Human BNP type - caused diuresis - heart failure - better for warm and wet decompensated heart failure (reduced ejection fraction) -
nesiritide (only with BNP)
Increase urine output by inhibiting NA and CL in the Distal tubule -
metalozone
Major side effect of sprinalactone -
gynecomastia
You have an 57 yo AA with a history of uncontrolled diabetes, elevated BP and tried lifestyle modification he has BP of 150/88 with ALBUMINERIA, which drugs start with?
Hydrochlorothiazide, BB, Losartan (ARB), CCB, or Vasodilator?
- you can use hydrochlorothiazide but not here (not in protein in urine), but instead CHOOSE losartan (we choose ARB over ACE-I because ACE-I not offered, usually ACE first) * DON’T PICK YOUR ANSWER BEFORE READING ALL THE OPTIONS*
COPD requires meds for his angina attacks.. .which drug do we want? -
NOT beta blocker - instead we want verapimil because COPD is R side dheart problem (non DHP and someone with pulmonary condition)
Will cause Torsades De Pointes - lengthened qT over 500 we are worried- which drugs cause this?!?
- look at this slide Zpack will cause lengthening - TDP also caused by: Sotalol, Amiodarone, Quinidine, (all class IA's), Macrolide ABX (Zpak), ONdansetron, granisetron, Antidepressents, antipsychotics, sumatriptan
metoprolol DOC for long Qt
DOC for prolonged QT?
Metoprolol
This drug causes ototoxicity?
- furosemide betusomide etc the loops
emergency situation - everyone starts with water pill, than CCB, and ACE and ARB if they have porteinuriea especially for African Americans
Not exactly sure the context here…
Glaucoma probably BB’s before…
Loop diuretics
DCT and thiazides - SE’s
hyperglycemia, hypokalemia, hypercalcemia, and hyperlipidemia
Stage 2 - need two drugs -
water pill (hydrochlorithiazide or chlorothalidone) and ACEI or ARB
Clonidine initially for
urgent HTN
HTN Emergency classifications?
Stroke LOC Memory loss Crushing chest pain Damage to eyes or kidneys aortic dissection Angina (unstable chest pain) Pulmonary edema preeclampsia
HTN urgency classifications?
severe headache
SOB
Nosebleeds
severe anxiety
Urgent vs emergent on this exam - emergency think Blurred vision is…
emergency
DOC for Eclampsia -
nifedipine
Pheochromocytoma DOC -
BB’s phentoelamine
Nitro is always the best vasodilator…
Nitroprusside -SE =
cyanide