Review

Question 1

MOA of haloperidol

Answer 1

D2 receptor antagonist

Question 2

AE of haloperidol

Answer 2

HyperPRL and EPS

Question 3

Name the tract that causes positive sx in schizophrenia.

Answer 3

Mesolimbic tract

Question 4

Name the tract that haloperidol’s D2 receptor antagonist affects that causes heyper PRL - dop inhibits PRL release, so decreased dop = incr PRL

Answer 4

Tubuloinfundibular

Question 5

Name the tract that haloperidol’s D2 receptor antagonist affects that causes EPS

Answer 5

Nigrostriatal

Question 6

Potency and SE of chlorpromazine and thioridazine

Answer 6

Less EPS, more anticholinergic (wet)

Question 7

What antipsychotic has SE: purple grey metallic rash over sun exposed ares.

Answer 7

Chlorpromazine

Question 8

What antipsychotic has SE: prolonged QTc and pigmentary retinopathy
?

Answer 8

Thoridazine

Question 9

Tx of akathesia

Answer 9

Decrease antipsychotic dose and propanolol, or benzo

Question 10

Tx of acute dystonia dt antipsychotic (presents w/i 12hr)

Answer 10

Benztropine or diphenhydramine

Question 11

Tx of TD

Answer 11

Stop antipsychotic and switch to clozapine

Question 12

Tx of NMS

Answer 12

Dantrolene or bromocriptine

Question 13

Atipical antipsychotic w/ highest risk of EPS and hyperPRL.

What is speccial about adminitration - when do you use?

Answer 13

Risperidone

Availabe in depo form

Question 14

Wt neutral antipsychotic but prolongs QTC

Answer 14

Ziprazodone (QTzzzzzz)

Question 15

Wt neutral byt increases akathesia

Answer 15

Aripiprazole (Akathesia = Arapiprazole)

Question 16

Antipsychotic Most assoc w. Wt gain and sedation

Answer 16

Olanzapine (O=big belly)

Question 17

What antipsychotic causes orthostasis and ataracts?

Answer 17

Quetiapine

Question 18

MC SE of clozapine.

Answer 18

Sedation and weight gain

Question 19

What labs should you get with clozapine?

Answer 19

CBC for leukocytosis

Lipids and cholesterol dt increase caused by clozapine

Question 20

Uses for SSRIs (six)

Answer 20

MDD
Bulemia
Anorexia
PTSD
OCD

Premature ejaculation

Question 21

Name the SSRI that you do not have to taper

Answer 21

Fluoxetine

Question 22

Describe 5HT discontinuation syndrome

Answer 22

HA, n/v/d, dizziness, fatigue

Question 23

N/v/d, tachycardia, HTN, hyperreflexia, MYOCLONIC JERKS

Answer 23

5Ht syndrome (SSRI + MAOI)

Question 24

Buproprion is CI in what three types of pts

Answer 24

Eating disorder, alcoholics, epileptics

Question 25

What SSRI can cause HTN crisis if taken with St. John's wart

Answer 25

Venlafaxine

Question 26

Pounding head, flushing, nausea, myoclonus after eating cheese, drinking red wine, tkaing decongestant or meperidine

Answer 26

HTN crisis dt tyramine ingestion + MAOI

Question 27

Tx MAOI HTN crisis with what

Answer 27

Phentolamione (alpha blocker)

Question 28

Failure of dexamethasone suppression test = what abd and what possible disorder

Answer 28

High cortisol dt stress, i.e. MDD

Question 29

Stroke where could cause mania in elderly?

Answer 29

Right MCA (right frontal hemisphere)

Question 30

What OTC drug can precipitate n/v/d, course tremor, ataxia, confusion, slurred speech in a pt taking lithium

Answer 30

NSAIDs - dont take advil Aspirin ius better

Question 31

T wave flattening or u wave inversion indivative of...

Answer 31

Lithium toxicithy.

Question 32

Clearance of lithium v. Depakote

Answer 32

Lithium is renally cleared. | Depakote is hepatically cleared.

Question 33

Bipolar + SJS

Answer 33

Lamotrigine

Question 34

Bipolar + elevated LFTs and hep

Answer 34

Depakote

Question 35

Bipolar = agranulocytosis

Answer 35

Carbamazepine

Question 36

Bipolar - two drugs that increase AFP in pregnant woman Preferred treatment for bipolar in pregnancy

Answer 36

Valporate or carbamazepine clonazEpam is preferred

Question 37

Social anxiety tx

Answer 37

SSRI orSNRI CBT If PERFORMANCE BASED - then Bblocker or benzo

Question 38

GAD definition - three or more of...

Answer 38

Significant impairment and ``` Restlessness/feeling on edge Fatigue Difficulty concentrating Irritability Muscle tension Sleep disturbance ```

Question 39

Acute stress disorder v. PTSD

Answer 39

LIFE THREATENING EVENT: Sx less than one mo of sx = Acute Stress Disorder Sx greater than one mo of sx = PTSD

Question 40

Define adjustmentn disorder and time frame.

Answer 40

Non-life threatening event; followed by significant impairment in function. Behavior/mood changes after w/i 3mo of stressful event.

Question 41

Define persistent grief: onset and lasting how long

Answer 41

Onset - >6m | Lasts 12mo or more