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Immunology: Cytokines > Review > Flashcards

Review Flashcards

1
Q

Hematopoiesis- stem cell factor

A

C-kit ligand

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2
Q

Hematopoiesis - myeloid cells

A

IL-3

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3
Q

Hematopoiesis -Granulocytes and monocytes

A

GM-CSF

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4
Q

Hematopoiesis - eosinophils

A

Il-5

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5
Q

Hematopoiesis - Basophils, mast cells

A

IL-3

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6
Q

Hematopoiesis - NK cells

A

IL-15

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7
Q

Hematopoiesis - B cells

A

IL-7

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8
Q

Hematopoiesis - T cells

A

IL-7 and Notch-1

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9
Q

PAMPs - gram +

A

Peptidoglycan

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10
Q

PAMPs - trypanosomes

A

GPI-linked protein

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11
Q

PAMPs Yeast, Fungi

A

Zymosan

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12
Q

PAMPs viruses

A

DsRNA, ssRNA

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13
Q

PAMPs gram - bacteria

A

LPS

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14
Q

Bacteria

A

Flagellum

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15
Q

PAMPs bacterial DNA

A

CpG unmethylated dinucleotide

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16
Q

TLR2

A

Peptidoglycan, CPI linked protein, zymosan

Heterodimer

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17
Q

TLR3

A

DsRNA

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18
Q

TLR4

A

LPS

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19
Q

TLR5

A

Flagellin

20
Q

TLR7

A

SsRNA

21
Q

TLR8

A

ssRNA

22
Q

TLR9

A

CpG unmethylated dinucleotides (bacterial DNA)

23
Q

CLRs

A

Mannose receptor
Dectin 1
Bacteria, fungi, parasite

Phagocytosis

24
Q

RLRs

A

DsRNA
Cytosolix
IFN alpha and beta

25
Q

NLRs

A

Bacterial cell wall components

Cytosolic

26
Q

Secreted peptides and protein
Defending and cathelicidin
(3 functions)

A

Inhibit and kill pathogens
Chemoattractant
Degranulate

27
Q

Secreted peptides and protein
IFN alpha and beta
2 functions

A

Inhibit virus replication, regulate activity

28
Q

Secreted peptides and protein

IL-1 (3 functions)

A

Enhance lymphocyte activity
Promote neutrophil production
Fever

29
Q

Secreted peptides and protein

IL-6 (3 functions)

A

Regulate lymphocyte activity
Produce neutrophils
Fever

30
Q

Secreted peptides and protein
TNF alpha
(3 functions)

A

Activate macrophages
Fever
Blood clotting

31
Q

Secreted peptides and protein

IL-12, IL-18

A

Induce Th1 differentiation
IFN-gamma production
Activate naive CD8+ and nk cells

32
Q

Secreted peptides and protein

IL-10

A

Antagonize inflammatory response

33
Q

Secreted peptides and protein

IL-8

A

Chemoattractant of neutrophils, basophils, immature DCs, T cells to infection site
G-coupled receptor

34
Q

Opsonin

4 types

A

Mannose binding lectin (MBL)
Ficolins
C reactive protein
Immunoglobulins

35
Q

Cytokines

TNF alpha, IL-1B, IL-6

A 
In response to bacteria products
Recruit neutrophils and macrophages
Dilate blood vessels, open junctions
Cause macrophages to secrète IL-1B
Blood clotting, recruit phagocytes and DCs
(LFA, iCAM)

IL-1B acute phase proteins (opsonins)

36
Q

Cytokines

IL-12

A

Made by macrophages and DCs in response to LPS, virus, intracellulaire bacteria, IFN-gamma
Activates NK; kill and produce IFN-gamma
Th1 differentiation to produce IFN-gamma, IL-2 (growth factor), IL-R

37
Q

Cytokines

IFN-alpha and beta

A 
Made in response to DsRNA
Alpha: made by macrophages and dc 
Beta: many cells
Indice viral résistant state (down regulate translation, make proteins to inhibit viral replication, upregulate MHC class 1)
Activate NK, kill and produce IFN-gamma
38
Q

Naive Th cell + TGF-beta

A

Treg

39
Q

Naive Th cell + IL-1B, IL-6, TGF-beta

A

Th17

40
Q

Naive Th cell + IL-4

A

Th2

41
Q

Naive Th cell + IFN-gamma and IL-12

A

Th1

42
Q

Treg secreted

A

IL-10
TGF-beta

Suppress immune response and inflammation

43
Q

Th17 secreted

A

IL-17

Inflammation

44
Q

Th2 secretes

A

IL-4, IL-5

Allergic response

45
Q

Th1 secreted

A

IFN-gamma
TNF alpha

Cell mediated immunity
Macrophage activation
Inflammation

Immunology: Cytokines (1 decks)

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