review Flashcards

1
Q

One of the most important intracellular process that requires energy

A

Formation of Peptide Linkages

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2
Q

How much energy stored in peptide bond?

A

500-5,000 cal

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3
Q

How much energy required to form 1 peptide linkage?

A

4 high-energy phosphate bonds (48,000 cal)

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4
Q

Ornithine Cycle converts ____ to _____.

A

ammonia to urea

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5
Q

What steps of Ornithine Cycle take place in the mitochondria?

A

CO2 + NH4 –> carbamoyl phosphate

carbamoyl phosphate + ornithine –> citrulline

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6
Q

What happens to fumarate in the ornithine cycle?

A

enters TCA cycle

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7
Q

What forms urea?

A

Arginine + H20 –> UREA + ornithine

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8
Q

Major Rate-Limiting Factor for almost all energy metabolism in the body

A

ADP

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9
Q

Best known stimuli for increasing rate of thyroid stimulating hormone

A

cold

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10
Q

How do thyroid levels affect energy levels?

A
Hypothyroid = Lethargic
Hyperthyroid = energetic
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11
Q

High insulin promotes usage of what for energy?

A

carbohydrates

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12
Q

Low insulin promotes usage of what for energy?

A

fat

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13
Q

Vascular supply of Liver

A

High blood flow & Low vascular resistance

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14
Q

Effect of cirrhosis on blood flow

A

increase resistance

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15
Q

Effect of clot blocking portal vein

A

blockage of return blood from spleen & intestines: increase capillary pressure in intestinal wall –> loss of fluid –> death

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16
Q

Ascites

A

large amount of fluid in abdominal cavity

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17
Q

elevated pressure in hepatic veins causes

A

ascites

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18
Q

How is heme transported in the blood?

A

Transferrin

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19
Q

What happens to bilirubin secreted into the intestine?

A

converted to urobilinogen via bacterial action

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20
Q

Metabolic Syndrome

A
obesity
insulin resistance
fasting hyperglycemia
increased lipid triglycerides
decreased HDL levels
HTN
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21
Q

Heme oxygenase catalyzes ____ to ____

A

heme to biliverdin

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22
Q

biliverdin –> ____ in the reticuloendothelial system

A

free (unconjugated) bilirubin

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23
Q

down-regulation of receptors

A

decreases target tissues responsiveness to hormones

24
Q

up-regulation of receptors

A

increases target tissue responsiveness to hormones

25
calcium binds to ____
calmodulin
26
Lipid Soluble Hormones
adrenal and steroidal hormones thyroid hormones retinoid hormones Vitamin D
27
Activated hormone receptor complex binds to what sequence of DNA?
Hormone Response Element
28
Somatotropes (acidophils)
Human Growth Factor
29
Corticotropes
ACTH
30
Thyrotropes
TSH
31
Gonadotropes
FSH & LH
32
Lactotropes
prolactin
33
What pump is on the basal membrane of thyroid cell?
Sodium Iodide Symporter (2:1)
34
What pump is on the apical membrane of thyroid cell?
Pendrin | chloride-iodide counter-transporter
35
Is T3 or T4 more active?
``` T3 (triiodothyronine) but T4 (thyroxine) is the major hormonal product ```
36
2 DIT =
Thyroxine (T4)
37
DIT + MIT =
triiodothyronine (T3)
38
Hyperthyroidism
``` causes: Graves' Disease, Adenoma Sx: high state of excitability intolerance to heat increased sweating mild to extreme weight loss varying degrees of diarrhea muscle weakness ```
39
Major Mineralocorticoid
Aldosterone
40
Effects of Aldosterone
increased sodium absorption by principal cells increased K+ secretion by principal cells increased H+ secretion by intercalated cells (Increases ECF/Blood Volume)
41
Aldosterone secreted from
zona glomerulosa | outermost adrenal cortex
42
Decreased Blood Volume --> Decreased Renal Perfusion Pressure -->
increased renin secretion
43
Renin
activates angiotensinogen --> angiotensin I (ACE converts angiotensin 1 --> angiotensin II
44
Angiotensin II
corticosterone --> ALDOSTERONE
45
Major Glucocorticoid
Cortisol
46
Glucocorticoids secreted from
Zona Fasciulata in adrenal cortex
47
Functions of Glucocorticoids
stimulates gluconeogenesis: "Adrenal Diabetes" increase protein catabolism mobilizes amino acids from extra hepatic tissues enhances transfer of amino acids into hepatic cells increases enzymes required to convert AAs to glucose decrease glucose utilization by cells increase Lipolysis **Resolution of Inflammation & Inhibits Immune Response
48
Hypoadrenalism
1˚ (Addison's) due to injury of adrenal cortex 2˚ due to impaired fxn of pituitary gland mineralocorticoid deficiency glucocorticoid deficiency melanin pigmentation
49
Hyperadrenalism
Cushing's Disease | "Buffalo Torso"
50
If calcium intake is 1,000 mg/day - how much excreted in feces?
900
51
Hypocalcemia
carpopedal spasm ~6mg/dl | lethal ~4mg/dl
52
Active form of Vitamin D
1,25-dihydroxycholecalciferol
53
calcium-binding protein in the intestinal epithelium
calbindin
54
cholecalciferol (vit D3) where?
skin
55
Vit D3 to liver
25-hydroxycholecalciferol
56
where is Vitamin D activated?
in kidney via PTH
57
What does vitamin D do in the body?
promotes intestinal absorption of calcium