Review Flashcards
1
Q
Deficiencies in what clotting factors can cause signficant bleeding?
A
- Factors 8, 9 (hemophilias)
- vWF
2
Q
Steps in Primary Hemostasis:
A
- Endothelium injured and basement membrane exposed.
- vWF binds to exposed collagen.
- vWF elongates into an open conformation revealing platelet binding sites.
- Platelets bind to vWF, become active, and release granules.
- More platelets recruited and aggregate onto elongated vWF.
- Platelets change shape and aggregate.
- Platelet plug forms.
3
Q
Factors of the extrinsic pathway:
A
- Tissue factor
- Factor 7
4
Q
The initiation complex from the extrinsic pathway is:
A
TF:F7a:F9a
5
Q
The common pathway:
A
F10:F5:Prothrombin:Thrombin:Fibrin
6
Q
Catalyst clotting factors are:
A
5 and 8
- 5 and 10 (faster prothrombin to thrombin)
- 8 and 9 (more F10)
7
Q
Intrinsic pathway factors are:
A
F12:F11:F9:F13
8
Q
Vitamin K dependent Clotting Factors:
A
2, 7, 9, 10
9
Q
Functions of vWF:
A
- accordion/landing site for platelets
- extends half-life of F8
10
Q
Thrombomodulin:
A
- anticoagulant
- sink for thrombin
- thrombin-thrombomodulin activates Protein C
11
Q
Protein C and Protein S:
A
- Anticoagulants
- Protein S cofactor for Protein A
- APC shuts off catalysts F5 and F8
12
Q
von Willebrand Disease:
A
- platelets don’t adhere properly
- F8 has very short half-life
- most common inherited bleeding disorder
13
Q
What is the most commonly inherited bleeding disease?
A
von Willebrand disease
14
Q
What is the most commonly inherited clotting disease?
A
Factor V Leiden deficiency
