Review Flashcards
What diuretic is used for pseudotumor cerebri?
acetazolamide
heart defects w/ Chromosome 22q11 deletions
Tetrology of fallot
truncus arteriosus
congenital rubella causes what heart defects?
PDA
PA stenosis
Turner’s Syndrome causes what heart defects?
infantile coarctation of aorta
bicuspid atresia
boot-shaped heart
tetrology of fallot (infant) RV hypertrophy (adult; COPD)
most common congenital cause of early cyanosis
tetrology of fallot
equations for Cardiac Output
CO = SV * HR CO = rate of O2 consumption / arterial O2 - venous O2
where do dorsal columns decussate?
medulla
where do lateral corticospinals decussate?
medullary pyramids
MAP equations
MAP = CO * TPR MAP = 2/3 diastolic + 1/3 systolic
derivatives of 3rd aortic arch?
common carotid artery
proximal part of internal carotid
derivatives of 4th aortic arch?
L = arch of adult aorta R = proximal part of R subclavian artery
derivatives of 6th aortic arch?
proximal part of pulmonary arteries
ductus arteriosus
what’s the antidote for toxins: t-PA, streptokinase
aminocaproic acid
what’s the antidote for toxins: digitalis
anti-digoxin Antibody fragments
what ligaments are typically injured during an ankle sprain?
anterior talofibular ligament
Always Tears First Ligament
whats the leading cause of knee pain in patients under 45?
patellofemoral syndrome
what ligament contains uterine vessels?
cardinal ligament
-connects cervix to side wall of pelvis
what does the round ligament connect?
uterine fundus to the labia majora
what is associated w/ extrophy of the bladder? what is extrophy of the bladder?
epispadias
lymphatic drainage of the ovaries/testes
para-aortic lymph nodes
lymphatic drainage of the distal 1/3 of the vagina/vulva/scrotum
superficial inguinal nodes
lymphatic drainage of the proximal 2/3 of the vagina/uterus
obturator
external iliac
hypogastric nodes
seminoma
testicaular germ cell tumor
malignant painless males 15-35yo "fried-egg" appearance increased PLAP = placental alkaline phosphatase
yolk sac (endodermal sinus) tumor testicaular germ cell tumor
Schiller-Duval bodies –> resemble glomeruli
high AFP
Choriocarcinoma
testicaular germ cell tumor
malignant, high hCG
hematogenous spread to the lungs
hCG = LH analog –> gynecomastia
teratoma
testicaular germ cell tumor
males = malignant
benign in children
high hCG
AFP in 50% cases
embryonal carcinoma
testicaular germ cell tumor
malignant, painful
glandular/papillary morphology
often mixed w/ other types
may have high hCG + high AFP when mixed
leydig cell
non-germ cell testicular tumor
Reinke crystals
androgen –> gynecomastia in men, precocious puberty in boys
golden brown color
What bacteria are encapsulated?
Even Some Pretty Nasty Killers Have Shiny Bodies
E.Coli Strep Pnemoniae Pseudomonas Aeruginosa Neisseria Meningitidis Klebsiella Pneumoniae Haemophilus Influenzae Type B Salmonella Typhi Group B Strep
What disorders result from trinucleotide repeats?
X-Girlfriends First Aid Helped Ace My Test Fragile X = CGC Friedreich Ataxia = GAA Huntington's = CAG Myotonic Dystrophy = CTG
What 6 bacteria secrete enterotoxins (exotoxin that causes water and electrolyte imbalances of intestinal epithelium resulting in diarrhea)?
VIbrio Cholerae ETEC Staph Aureus Shigella Yersenia Clostridium Difficile
what are the 3 main causes of bacterial neonatal sepsis?
Group B Strep
E.Coli
Listeria Monocytogenes
what are the 4 MC bacterial causes of UTI?
E.Coli
Staph Saprophyticus
Klebsiella
Proteus Mirabilis
What are the sulfa-drug allergies?
Sulfa Pills Frequently Cause Terrible Acute Symptoms
Sulfasalazine Probenecid Furosemide Celecoxib Thiazides/TMP-SMX Acetazolamide Sulfonylureas
What diseases can cause Bells Palsy?
my Lovely bell Had An STD Lyme Disease Herpes Zoster AIDS Sarcoidosis Tumors Diabetes
what are T-cell markers?
CD3 TCR Helper = CD4 + CD40 ligand (activating B cells) Cytotoxic = CD8 CD28 (costim --> binds to B7 on APC)
HLA B27
PAIR Psoriatic Arthritis Ankylosing Spondylitis Inflammatory Bowel Disease Reiter's Syndrome
HLA DR3
Graves’s Disease
Type 1 Diabetes Mellitus
HLA DR4
Rheumatoid Arthritis
Type 1 Diabetes Mellitus
what markers are on dendritic cells?
MHC 1
APC = MCHII + B7
what cytokines do Th1 cells secrete?
IL-2 + IFNgamma –> kill stuff
IL-10 –> don’t make Th1
what cytokines do Th2 make?
IL-4 –> more TH2
IL-5
IL-10 –> don’t make Th1
What are B cell surface markers?
CD19, CD20, CD21
Ig
APC = MCHII + B7
CD40 (T cell activate B cell)
NK cell markers?
CD56
CD16 (binds Fc of IgG)
Macrophage cell markers?
CD14
CD40
APC = MHCII + B7
what protein initiates recombination of V(D)J sequences?
RAG-1 and RAG-2
Recombination Activating Gene Complex’s
what bacteria works by inhibiting/disabling Gi?
Bordetella Pertussus
what bacteria works by having bacterial adenylate cyclase (no G protein involved)
Bacillus Anthracis
what diseases can you gets shots for protective PASSIVE immunity? (4)
“To Be Healed Rapidly”
Tetanus toxin
Botulinum toxin
HBV (give active + passive immunity)
Rabies Virus (give active + passive immunity)
Live Viral Vaccines (6)
Varicella = chicken pox Small Pox influenza (intranasal) Polio (Sabin = oral) MMR = measles, mumps, rubella Yellow Fever
Inactivated/killed vaccines (5)
be CHIPR they're dead so you don't have to be Cholera Hepatitis A Influenza (intramuscular) Polio (Salk= injected) Rabies
when can you give live vaccines to AIDs patients? What should you give? What do you always give to HIV infants?
CD4 > 200
MMR
Varicella = chicken pox
Yellow Fever
rotavirus recommended for all infants w/ HIV
egg-based vaccines
influenza vaccine
yellow fever
egg allergy –> do skin test first
what gives rise to the jugular venous a, c, v waves?
a = atrial contraction c = ventricular contraction v = atrial filling against closed tricuspid valve
what happens if you have a C1 esterase inhibitor deficiency?
hereditary angioedema
ACE inhibitors are contraindicated
What happens if you have a C3 deficiency?
lots of sinus and respiratory tract infections
-Strep. Pneumo
-H. Influenza
increased suceptibility to type 3 hypersensitivity rxns
what do you get if you have C5-C9 deficiencies?
recurrent NEISSERIA bacteremia infections
what do you get if you are deficient in DAF (CD55) = GPI anchored enzyme
complement against your own RBC
paroxysmal noctural hemoglobinuria (PNH)
Hot T-Bone stEAk
Hot = IL-1 = fever T = IL-2 --> T cells Bone = IL-3 --> stimulates BM E --> IL-4 --> IgE production A --> IL-5 --> IgA production
note that IL-4 –> stimulates IgE production while IL-5 –> stimulates eosinophils
neutrophil chemotactic agents
IL-8 “cleanup on isle 8!”
C5a
Leukotriene B4
what bands do you find actin and myosin? Where do they attach to?
An Interesting Zoo
Actin, alone in I-band, attaches to Z-line
Must Have Mammals
Myosin, alone in H-band, attaches to M-line
slow adapting receptors on skin?
superficial = merkel (pressure, position) deep = ruffini
fast adapting receptors on skin?
superficial = meissner (light touch) deep = Pacinian (vibration, pressure)